Alpha78(EF7)Asn-->Asp is a posttranslational modification in Hb J-Singapore [alpha78(EF7)Asn-->Asp;alpha79(EF8)Ala-->Gly].

In Hb J-Singapore, the alpha78(EF7)Asn-->Asp and alpha79(EF8)Ala-->Gly substitutions were initially thought to be genetic mutations. Subsequent studies on other similar hemoglobin variants suggested that the Asn-->Asp change was a posttranslational modification. Nevertheless, lack of DNA evidence made it difficult to confirm the deamidation in Hb J-Singapore.

Managing bone loss in revision total hip arthroplasty: the acetabulum.

Osteolysis is the greatest threat to the viability of modern acetabular implants. The etiology and natural history of osteolysis remain unknown. Patients with cementless implants who have osteolysis are challenging to treat.

The value of autofluorescence as a diagnostic feature of acute promyelocytic leukemia.

Autofluorescence is an immunophenotypic characteristic of leukemic blasts in acute promyelocytic leukemia (APL). We examined the fluorescent intensity of isotype controls in 25 cases of APML and 25 controls with acute myeloid leukemia. The fluorescence of the FITC- and PE-conjugated controls was consistently higher in APML.

The mini-incision direct lateral approach in primary total hip arthroplasty.

Unlabelled: Patients are inquiring about mini-incision primary total hip arthroplasty with increasing frequency. There are no published randomized controlled trials to substantiate claims that the mini-incision direct lateral approach is better than a standard approach. The purpose of our study was to review our initial experience with the mini-incision technique through the direct lateral approach, with the intent of implementing a randomized controlled trial if the approach could be shown as safe and effective.

Stickler syndrome.

Stickler syndrome is a relatively rare condition (approximately 1 in 10,000), caused by a defective collagen gene and characterised by high myopia, high risk of retinal detachment and flattened facial features. An outline of the condition, its systemic and ocular manifestations and optometric management are described.