Publications by authors named "David A Heise"
Article Synopsis
- Human genetic studies often lack diversity, which limits understanding of disease causes and health disparities.
- The Department of Veterans Affairs Million Veteran Program analyzed data from a diverse group of 635,969 veterans, revealing 13,672 genomic risk loci, with significant findings particularly from non-European populations.
- The research identified causal variants across 613 traits, showing that genetic similarities exist across populations and emphasizing the importance of including underrepresented groups in genetic research.
Genome-wide association studies (GWAS) have underrepresented individuals from non-European populations, impeding progress in characterizing the genetic architecture and consequences of health and disease traits. To address this, we present a population-stratified phenome-wide GWAS followed by a multi-population meta-analysis for 2,068 traits derived from electronic health records of 635,969 participants in the Million Veteran Program (MVP), a longitudinal cohort study of diverse U.S.
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