Publications by authors named "David A G Andrade"
Article Synopsis
- - iNKT cells play a crucial role in immunity by being the primary source of IFN- after infection and are necessary for enhancing macrophage responses, particularly against fungal infections.
- - Mice lacking iNKT cells demonstrated weakened immune responses, resulting in less inflammation and a higher fungal burden in the lungs and spleen after being infected with a virulent strain.
- - Administering an exogenous ligand (-GalCer) to activate iNKT cells improved the immune response and reduced fungal levels, highlighting the potential of targeting iNKT cells to enhance resistance against infections.
Background: Although different studies associated sleep deprivation (SD) with systemic inflammatory changes, the effect of sleep duration on the pathology of allergic chronic diseases is poorly understood.
Objective: We sought to evaluate the influence of SD on allergen-induced pulmonary inflammation.
Methods: Ovalbumin (OVA)-sensitized C57BL/6 mice were exposed to a first set of intranasal OVA challenge under SD or healthy sleep (HS) conditions, followed by a second OVA challenge, 1 week apart.