Publications by authors named "David A Erickson"
Bicifadine [DOV 220,075; (+/-)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]-hexane HCl)] is a non-narcotic analgesic that is effective in animal models of acute and chronic pain.
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- The study investigated how the drug bicifadine is metabolized in the liver cells of mice, rats, monkeys, and humans using advanced chromatography techniques.
- Two main metabolic pathways were identified: one dependent on NADPH that converts bicifadine into a hydroxymethyl metabolite (M2), primarily involving the enzyme CYP2D6, and another independent pathway that produces a lactam metabolite (M12) through monoamine oxidase (MAO)-B.
- The research highlights that in humans, the key enzymes for bicifadine metabolism are CYP2D6 and MAO-B, with notable differences in metabolic activity across the different species.