Efficacy and Safety of Low Dose Naltrexone for Chronic Pain.

Naltrexone is a mu-opioid receptor antagonist increasingly used as an analgesic for chronic pain at low doses. This retrospective, observational cohort study was conducted at an academic medical center to evaluate low-dose naltrexone (LDN) efficacy and describe its use in routine clinical practice. Adults receiving LDN, doses <10 mg for ≥1 month, seen at an outpatient pain clinic from January 1, 2014 to April 1, 2022 were included.

Quantifying organic carbon storage in temperate pond sediments.

Ponds may hold significant stocks of organic carbon in their sediments and pond creation may offer a practical application for land managers to increase carbon storage. However, ponds are overlooked in global carbon budgets. Their potential significance is suggested by the abundance of ponds throughout terrestrial biomes and their high carbon burial rates, but we lack measures of sediment carbon stocks from typical ponds.

Arsenic hazard in Cambodian rice from a market-based survey with a case study of Preak Russey village, Kandal Province.

This study comprises a market-based survey to assess the arsenic (As) hazard of Cambodian rice, encompassing rice from seven Cambodian provinces, comparisons with rice imported from China, Vietnam and Thailand, and assessments of 15 rice varieties. Rice samples (n = 157) were collected from four large markets in Kandal Province and analysed for As using inductively coupled mass spectrometry. The mean As concentration for Cambodian rice (0.

Microbial ecology of arsenic-mobilizing Cambodian sediments: lithological controls uncovered by stable-isotope probing.

Microbially mediated arsenic release from Holocene and Pleistocene Cambodian aquifer sediments was investigated using microcosm experiments and substrate amendments. In the Holocene sediment, the metabolically active bacteria, including arsenate-respiring bacteria, were determined by DNA stable-isotope probing. After incubation with (13) C-acetate and (13) C-lactate, active bacterial community in the Holocene sediment was dominated by different Geobacter spp.

Deep venous thrombosis after office vasectomy: a case report.

Introduction: Postoperative pulmonary embolism is considered a complication of major surgery. However, thromboembolism can also occur following minor procedures. We report a case of a major embolic event following a straightforward office vasectomy.

Partial oesophageal perforation associated with cold carbonated beverage ingestion.

We present a rare case of spontaneous intramural oesophageal perforation after the rapid ingestion of a cold carbonated beverage. A previously well patient presented with sudden onset of severe retrosternal pain associated with pain on swallowing. A contrast computed tomography scan and gastroscopy confirmed the diagnosis.