Publications by authors named "David A Carr"

Article Synopsis
  • The alternative NF-κB pathway, activated by IKKα through NIK, is significant in basal breast cancer development, particularly from luminal progenitor cells.
  • IKKα-deficient mice showed slower tumor growth but similar tumor characteristics to wild-type mice, indicating that IKKα activation isn’t essential for basal-like tumors.
  • Findings suggest that NIK stabilization may be enough for p100/NFKB2 processing, and while IKKα is crucial for normal mammary gland development, it isn’t necessary for basal tumor formation.
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