Publications by authors named "David A Carr"
Tumour Biol
September 2022
Article Synopsis
- The alternative NF-κB pathway, activated by IKKα through NIK, is significant in basal breast cancer development, particularly from luminal progenitor cells.
- IKKα-deficient mice showed slower tumor growth but similar tumor characteristics to wild-type mice, indicating that IKKα activation isn’t essential for basal-like tumors.
- Findings suggest that NIK stabilization may be enough for p100/NFKB2 processing, and while IKKα is crucial for normal mammary gland development, it isn’t necessary for basal tumor formation.
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