Publications by authors named "David A Burks"
Article Synopsis
- This text outlines a clinical framework aimed at diagnosing and treating interstitial cystitis/bladder pain syndrome based on a systematic review of literature from 1983 to 2009.
- While there was limited evidence for diagnosis, 86 treatment articles were assessed to develop a treatment guideline, which classifies evidence strength into high, moderate, or low ratings.
- The guidelines include an algorithm for management and identify various treatment options while noting that approaches may evolve as new evidence emerges.
Purpose: We evaluated the efficacy and tolerability of mycophenolate mofetil in patients with treatment refractory interstitial cystitis/painful bladder syndrome.
Materials And Methods: A total of 210 patients with interstitial cystitis/painful bladder syndrome were to be randomized into a multicenter, placebo controlled trial using a 2:1 randomization. Participants in whom at least 3 interstitial cystitis/painful bladder syndrome specific treatments had failed and who had at least moderately severe symptoms were enrolled in a 12-week treatment study.
Purpose: Amitriptyline is frequently used to treat patients with interstitial cystitis/painful bladder syndrome. The evidence to support this practice is derived mainly from a small, single site clinical trial and case reports.
Materials And Methods: We conducted a multicenter, randomized, double-blind, placebo controlled clinical trial of amitriptyline in subjects with interstitial cystitis/painful bladder syndrome who were naïve to therapy.