Publications by authors named "David A Bennet"
Article Synopsis
- Alzheimer's disease (AD) is influenced by a mix of genetic, epigenetic, and environmental factors, with DNA modifications like methylation (5mC) and hydroxymethylation (5hmC) playing key roles in gene expression regulation.
- Researchers found a significant association between rare TET1 gene variants and early-onset AD through targeted resequencing, alongside identifying differentially hydroxymethylated regions in genes vital for regulating methylation.
- In experiments using a mouse model, the loss of TET1 led to increased amyloid plaque accumulation and notable changes in gene expression linked to neuronal health, highlighting the potential role of TET enzymes in AD progression.
Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies.
J Neuropathol Exp Neurol
September 2021
Patients with essential tremor (ET) frequently develop concurrent dementia, which is often assumed to represent co-morbid Alzheimer disease (AD). Autopsy studies have identified a spectrum of tau pathologies in ET and tau isoforms have not been examined in ET. We performed immunoblotting using autopsy cerebral cortical tissue from patients with ET (n = 13), progressive supranuclear palsy ([PSP], n = 10), Pick disease ([PiD], n = 2), and AD (n = 7).
View Article and Find Full Text PDF