Thyroid homeostasis in B6C3F1 mice upon sub-chronic exposure to trifluoroiodomethane (CFI).

Trifluoroiodomethane (CFI) is a fire suppressant gas with potential for use in low global-warming refrigerant blends. Data from studies in rats suggest that the most sensitive health effect of CFI is thyroid hormone perturbation, but the rat is a particularly sensitive species for disruption of thyroid homeostasis. Mice appear to be less sensitive than rats but still a conservative model with respect to humans.