Publications by authors named "Dave Chuter"
Article Synopsis
- The FDA's Project Optimus is encouraging the use of Patient-reported Outcome (PRO) data to better assess how tolerable new cancer therapies are in early clinical trials, moving beyond just clinician evaluations of side effects.
- A virtual session engaged various experts and patient advocates to discuss how to effectively incorporate PROs in trial designs, highlighting the value of patient input in this process.
- While there is support for using PROs, participants expressed concerns that it might lead to lower recommended doses and hesitation among patients to accurately report symptom severity.
PEARLS is a multi-stage randomised controlled trial for prostate cancer patients with pelvic and/or para-aortic PSMA-avid lymph node disease at presentation. The aim of the trial is to determine whether extending the radiotherapy field to cover the para-aortic lymph nodes (up to L1/L2 vertebral interspace) can improve outcomes for this patient group.
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