[Dynamics of immunologic indicators in children with severe forms of suppurative-septic diseases after the exchange-substitute plasmapheresis].

Time course of the immunity system parameters was followed in children suffering from grave endotoxicosis forms treated by discrete plasmapheresis (DPA) as the emergency therapeutic measure. T, T-active, B lymphocytes, O cells, immunoglobulins A, G, M were analyzed, as were the counts of phagocytizing leukocytes and circulating immune complexes. The infectious process was found to lead to a temporary relative secondary immunodeficiency.

[The reactogenicity and immunological efficacy of a Klebsiella vaccine in donors].

Klebsiella vaccine, when injected subcutaneously to donors, proved to be faintly reactogenic and safe. The injection of the vaccine had no effect on changes in the morphological composition of peripheral blood and on liver function. In persons with the initially low content of IgG an increase in this characteristic was observed after immunization.

[Plasmapheresis in severe forms of suppurative-septic diseases in children].

Under analysis is the first experience with the application of discrete plasmapheresis in 44 children aged from 6 months to 14 years for detoxication of severe forms of pyo-septic diseases. The method of discrete plasmapheresis is described. The method was shown to have a favourable influence upon hemodynamics and some parameters of the cell and humoral immunity.

[Production of a hyperimmune antitoxic donor plasma against Pseudomonas aeruginosa].

Research work has been carried out with the aim of obtaining hyperimmune antitoxic plasma against Pseudomonas aeruginosa. Hyperimmune plasma active against P. aeruginosa toxin has been obtained from donors immunized with P.