[The effect of ximedon on cholesterol metabolism and experimental atherosclerosis in rabbits].

The effects produced by the two pyrimidine derivatives pyridinol carbamate (parmidine) and xymedon on cholesterol metabolism and experimental atherosclerosis were comparatively studied in rabbits. The rabbits were fed either a chow containing cholesterol (200 mg/kg body weight) or the same diet also containing xymedon (30 mg/kg body weight) or pyridinol carbamate (30 mg/kg body weight). Total plasma cholesterol showed 5.

[The effect of dimethyl-(imidazol-1-yl) methanesulfonic acid on experimental atherogenesis in rabbits].

The hypocholesterolemic and antiatherosclerotic activities of the new imidazole derivative dimethyl-(imidazole-1-yl) methanesulfonic acid (1273) were investigated in rabbits fed through a probe either cholesterol, 200 mg/kg body weight, suspended in sunflower seed oil or that supplemented by imidazole, 15 mg/kg body weight, or its derivative 1273, 30 mg/kg body weight. Total cholesterol showed an 8-fold increase in all rabbit groups as compared to that in the animals fed a routine laboratory chow. In the agent 1273-given animals, the aortic atherosclerotic lesion index (ALI) was 7.