An emerging zoonosis: molecular detection of multidrug-methicillin resistant Staphylococcus aureus from butchers' knives, livestock products and contact surfaces.

Methicillin-resistant Staphylococcus aureus (MRSA) transmission in livestock, community, and healthcare settings poses a significant public health concern both locally and globally. This study aimed to investigate the occurrence, molecular detection, and antibiogram of the MRSA strain in fresh beef, contact surfaces, and butchers' knives from the four major abattoirs (Karu, Gwagwalada, Deidei, and Kubwa) located in the Federal Capital Territory, Nigeria. A multi-stage sampling technique was used to collect 400 swab samples from butchers' knives (132), fresh beef (136), and contact surfaces (132).

Strategic Planning of a Joint SARS-CoV-2 and Influenza Vaccination Campaign in the UK.

The simultaneous administration of SARS-CoV-2 and influenza vaccines is being carried out for the first time in the UK and around the globe in order to mitigate the health, economic, and societal impacts of these respiratory tract diseases. However, a systematic approach for planning the vaccine distribution and administration aspects of the vaccination campaigns would be beneficial. This work develops a novel multi-product mixed-integer linear programming (MILP) vaccine supply chain model that can be used to plan and optimise the simultaneous distribution and administration of SARS-CoV-2 and influenza vaccines.

Damping and Stiffness Analysis of Sandwich Beam with 3D-Printed Honeycomb Core Filled with Magnetorheological Elastomer (MRE): An Experimental Approach.

The current study focuses on the production and experimental examination of sandwich beams consisting of an aluminum face sheet and 3D-printed honeycomb cores that are filled with magnetorheological elastomer (MRE). These cores are loaded with different ratios of (75/25)% and (50/50)% elastomer and magnetic particles, measured by weight. In order to ascertain the dynamic characteristics of sandwich beams, the constructed specimens were subjected to classic shock (free vibration) experiments, and these experiments were conducted under two conditions: with and without the application of a changing magnetic field at the free end and center of the beam.

Pandemic-response adenoviral vector and RNA vaccine manufacturing.

Rapid global COVID-19 pandemic response by mass vaccination is currently limited by the rate of vaccine manufacturing. This study presents a techno-economic feasibility assessment and comparison of three vaccine production platform technologies deployed during the COVID-19 pandemic: (1) adenovirus-vectored (AVV) vaccines, (2) messenger RNA (mRNA) vaccines, and (3) the newer self-amplifying RNA (saRNA) vaccines. Besides assessing the baseline performance of the production process, impact of key design and operational uncertainties on the productivity and cost performance of these vaccine platforms is quantified using variance-based global sensitivity analysis.

Model-Based Planning and Delivery of Mass Vaccination Campaigns against Infectious Disease: Application to the COVID-19 Pandemic in the UK.

Vaccination plays a key role in reducing morbidity and mortality caused by infectious diseases, including the recent COVID-19 pandemic. However, a comprehensive approach that allows the planning of vaccination campaigns and the estimation of the resources required to deliver and administer COVID-19 vaccines is lacking. This work implements a new framework that supports the planning and delivery of vaccination campaigns.

Dynamic Behavior of Sandwich Structures with Magnetorheological Elastomer: A Review.

Magnetorheological (MR) materials are classified as smart materials that can alter their rheological features once exposed to peripheral magnetic fields. MR materials have been a standard and one of the primary smart materials for the last few decades due to their outstanding vibration control performance in adaptive sandwich structures and systems. This paper reviews the vibration suppression investigations of flexible constructions using MR elastomers (MREs).

Comparative Analysis of Cutting Forces, Torques, and Vibration in Drilling of Bovine, Porcine, and Artificial Femur Bone with Considerations for Robot Effector Stiffness.

Bone drilling is known as one of the most sensitive milling processes in biomedical engineering field. Fracture behavior of this cortical bone during drilling has attracted the attention of many researchers; however, there are still impending concerns such as necrosis, tool breakage, and microcracks due to high cutting forces, torques, and high vibration while drilling. This paper presents a comparative analysis of the cutting forces, torques, and vibration resulted on different bone samples (bovine, porcine, and artificial femur) using a 6dof Robot arm effector with considerations of its stiffness effects.

Evaluation of Health Risk Level of Hand-Arm and Whole-Body Vibrations on the Technical Operators and Equipment in a Tobacco-Producing Company in Nigeria.

Vibration is experienced when a body is subjected to either internal or external forces which cause oscillation, with most operators of industrial equipment often exposed to high dosage, higher than the stipulated values. In this research, Digital Real-Time Frequency Analyzer (RSA 5106A) was used, while the results obtained were evaluated and compared with the health guidelines of the ISO 2631-1 : 1997 and ISO 2631-5 : 2004 standards, as described in the Health Guidance Caution Zone for a daily exposure action value (EAV) of 0.47 m/s and a daily exposure limit value (ELV) of 0.

In vivo antitrypanosomal effects of some ethnomedicinal plants from Nupeland of north central Nigeria.

Four medicinal plants Acacia nilotica, Bombax buonopozense, Terminalia avicennioides and Zanthoxylum zanthoxyloides traditionally used for treatment of sleeping sickness in Nupeland were investigated for in vivo antitrypanosomal activity. Methanol extracts of different parts of each plant (stem barks and fruits) were obtained and evaluated for their in vivo antitrypanosomal activities against Trypanosoma brucei brucei. Phytochemical screening of the methanol extracts of each plant were performed by standard procedures.