The paper presents the data on the clinical course and laboratory diagnosis of Brill's disease in 30 patients. The absence of absolute and not infrequently basic and indicating signs of the disease as well as its frequent course in the presence of the concurrent diseases significantly hinder its clinical diagnosis, particularly at the initial stage of the disease. Unwanted clinical and epidemiological consequences could be avoided only in case of a constant medical alertness and understanding of specificity of the current course of Brill's disease as well as a provisional hospitalization within 5 days of all the patients with unclear diagnosis who have fever into the infectious department of a hospital.
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