Completing the Cabrera Circle: deriving adaptable leads from ECG limb leads by combining constraints with a correction factor.

We present a concept for processing 6-lead electrocardiography (ECG) signals which can be applied to various use cases in quantitative electrocardiography.Our work builds upon the mathematics of the well-known Cabrera sequence which is a re-sorting of the six limb leads (,,,,,) into a clockwise and physiologically-interpretable order. By deriving correction factors for harmonizing lead strengths and choosing an appropriate basis for the leads, we extend this concept towards what we call the 'Cabrera Circle' based on a mathematically sound foundation.

Benchmarking the Impact of Noise on Deep Learning-Based Classification of Atrial Fibrillation in 12-Lead ECG.

Electrocardiography analysis is widely used in various clinical applications and Deep Learning models for classification tasks are currently in the focus of research. Due to their data-driven character, they bear the potential to handle signal noise efficiently, but its influence on the accuracy of these methods is still unclear. Therefore, we benchmark the influence of four types of noise on the accuracy of a Deep Learning-based method for atrial fibrillation detection in 12-lead electrocardiograms.

Analysis of a Deep Learning Model for 12-Lead ECG Classification Reveals Learned Features Similar to Diagnostic Criteria.

Despite their remarkable performance, deep neural networks remain unadopted in clinical practice, which is considered to be partially due to their lack of explainability. In this work, we apply explainable attribution methods to a pre-trained deep neural network for abnormality classification in 12-lead electrocardiography to open this "black box" and understand the relationship between model prediction and learned features. We classify data from two public databases (CPSC 2018, PTB-XL) and the attribution methods assign a "relevance score" to each sample of the classified signals.

Structured, Harmonized, and Interoperable Integration of Clinical Routine Data to Compute Heart Failure Risk Scores.

Risk prediction in patients with heart failure (HF) is essential to improve the tailoring of preventive, diagnostic, and therapeutic strategies for the individual patient, and effectively use health care resources. Risk scores derived from controlled clinical studies can be used to calculate the risk of mortality and HF hospitalizations. However, these scores are poorly implemented into routine care, predominantly because their calculation requires considerable efforts in practice and necessary data often are not available in an interoperable format.

The bees of Lebanon (Hymenoptera: Apoidea: Anthophila).

The study of wild bees has markedly increased in recent years due to their importance as pollinators of crops and wild plants, and this interest has been accentuated by increasing evidence of global declines in their abundance and species richness. Though best studied in Europe and North America, knowledge on the current state of wild bees is scarce in regions where they are particularly diversified, such as the Mediterranean basin. The eastern Mediterranean country of Lebanon, located at the heart of the Levant in a biodiversity hotspot, is particularly poorly studied.

The wild bees (Hymenoptera: Apoidea) of Morocco.

Morocco is a well known hot-spot of biodiversity in the Mediterranean basin. While some taxa like vascular plants are relatively well recorded, important groups of pollinators like bees are still understudied. This article presents an updated checklist of the bee species of Morocco and includes a summary of global and regional distribution of each species.

Biomechanical analysis of temporomandibular joint dynamics based on real-time magnetic resonance imaging.

Aim: The traditional hinge axis theory of temporomandibular joint (TMJ) dynamics is increasingly being replaced by the theory of instantaneous centers of rotation (ICR). Typically, ICR determinations are based on theoretical calculations or three-dimensional approximations of finite element models.

Materials And Methods: With the advent of real-time magnetic resonance imaging (MRI), natural physiologic movements of the TMJ may be visualized with 15 frames per second.

A Privacy Preserving Approach to Feasibility Analyses on Distributed Data Sources in Biomedical Research.

Funding agencies and field experts promote reuse of scientific data and biomaterial beyond the scope of the original project. The availability of research data, however, is limited by the interest of original authors as well as the privacy rights of the study participants, especially in the biomedical sciences. On the other hand, for an available data set to be a useful contribution to the scientific community, it has to be findable and accessible with reasonable effort.

Designing meaningful outcome parameters using mobile technology: a new mobile application for telemonitoring of patients with heart failure.

Aims: Health data captured by commercially available smart devices may represent meaningful patient-reported outcome measures (PROMs) in heart failure (HF) patients. The purpose of this study was to test this hypothesis by evaluating the feasibility of a new telemonitoring concept for patients following initial HF hospitalization.

Methods And Results: We designed a cardio patient monitoring platform (CPMP) that comprised mobile iOS-based applications for patients' smartphone/smartwatch and the equivalent application on a physicians' tablet.

The genus Hylaeus Fabricius in Central Asia (Hymenoptera: Apoidea: Colletidae).

All presently available information about bees of the genus Hylaeus F. in Central Asia is summarized. Seventy species are currently known from this area.

In the footsteps of history: the bees of the genus Hylaeus Fabricius (Hymenoptera, Apoidea: Colletidae) collected by V.I. Roborovsky and P.K. Kozlov in Northwest China (1895-1926).

An annotated list of 19 species of Hylaeus collected by the famous Russian explorers and travellers V.I. Roborovsky and P.

A Musashi Splice Variant and Its Interaction Partners Influence Temperature Acclimation in .

Microalgae contribute significantly to carbon fixation on Earth. Global warming influences their physiology and growth rates. To understand algal short-term acclimation and adaptation to changes in ambient temperature, it is essential to identify and characterize the molecular components that sense small temperature changes as well as the downstream signaling networks and physiological responses.

Antagonistic bacteria disrupt calcium homeostasis and immobilize algal cells.

Photosynthetic unicellular organisms, known as microalgae, are key contributors to carbon fixation on Earth. Their biotic interactions with other microbes shape aquatic microbial communities and influence the global photosynthetic capacity. So far, limited information is available on molecular factors that govern these interactions.

Type revision of Asiatic bees of the genus F. described by Ferdinand Morawitz (Hymenoptera: Apoidea, Colletidae).

The type specimens of the bee genus Hylaeus Fabricius, 1793 described by Ferdinand Morawitz from Asia and deposited in the Zoological Museum of the Moscow State University and in the Zoological Institute, Russian Academy of Sciences St. Petersburg, are critically reviewed. Precise information with illustrations of types for 39 taxa is provided.

The description of the human knee as four-bar linkage.

Purpose: We investigate the dependence of the kinematics of the human knee on its anatomy. The idea of describing the kinematics of the knee in the sagittal plane using four-bar linkage is almost as old as kinematics as an independent discipline. We start with a comparison of known four-bar linkage constructions.

The upper ankle joint: Curvature morphology of the articulating surfaces and physiological function.

Purpose: The curvature morphology of the articulating surfaces determines the physiological movement pattern. We quantitatively examined the curvature morphology of the tibiotalar articulating surfaces and specified their geometric contact patterns.

Methods: Geometrically equivalent cartographic nets were marked on the talar and tibial articulating surfaces of true-to-scale moldings of 20 human ankle joints (intervals of 5 mm) to relate corresponding articulating units of the surfaces.

The bees (Hymenoptera: Apoidea) of the Maltese Islands.

This study presents the first checklist of the bees of the Maltese Islands and includes notes on the distribution of each species. A total of 95 species belonging to five bee families are recorded: Andrenidae (17 species), Apidae (34 species), Colletidae (6 species), Halictidae (15 species) and Megachilidae (23 species). Lasioglossum callizonium (Pérez, 1896) is recorded for the first time from the Maltese Islands.

The thumb carpometacarpal joint: curvature morphology of the articulating surfaces, mathematical description and mechanical functioning.

Purpose: The purpose is to present a mathematical model of the function of the thumb carpometacarpal joint (TCMCJ) based on measurements of human joints. In the TCMCJ both articulating surfaces are saddle-shaped. The aim was to geometrically survey the shapes of the articulating surfaces using precise replicas of 28 TCMCJs.

The genus Hylaeus Fabricius in Mongolia, an updated species inventory (Hymenoptera: Apoidea, Colletidae).

Since the last inventory of Hylaeus species of Mongolia (Dathe 1986a) extensive new collections have been evaluated. An updated checklist of 38 species of Hylaeus so far known from Mongolia is provided, with comments on their biogeographical assignment. Two new species, Hylaeus (Hylaeus) kozlovi sp.

Additional records of the genus Hylaeus Fabricius, 1793 (Hymenoptera: Apoidea: Colletidae) from Siberia, with description of a new species.

As a supplement to a previously published study on Siberian Hylaeus species, we here report further records of twenty six rarely collected and little known species. Thirty two species are currently known from Siberia, including Hylaeus dorni Dathe, 1986, H. gredleri Förster, 1871, H.

Compensation of skeletal Class III malocclusion by isolated extraction of mandibular teeth: Part 2: Skeletal, dentoalveolar and soft tissue parameters in comparison with nonextraction Class III therapies.

Objectives: To retrospectively compare two compensatory approaches taken in skeletal Class III patients during the main treatment stage, including a study group of multiband treatment plus isolated extraction of mandibular teeth and a control group of multiband treatment without extraction of teeth.

Patients And Methods: The extraction group included 22 (12 female, 10 male) patients receiving compensatory multiband treatment for a mean of 3.47 ± 1.

The morphology of the articular surfaces of biological knee joints provides essential guidance for the construction of functional knee endoprostheses.

Purpose: In comparative examinations of kinematics of the knees of humans and pigs in flexional/extensional motion under compressive loads, the significant differential geometric essentials of articular guidance are elaborated to criticise the shaping of the articular surfaces of conventional knee-endoprostheses and to suggest constructional outlines that allow the endoprosthesis to adopt natural knee kinematics. Implantation is discussed with regard to the remaining ligamentous apparatus.

Methods: Twelve fresh pig knee joints and 19 preserved human knee joints were moved into several flexional/extensional positions.

Characteristic points and cycles in planar kinematics with application to the human gait.

Purpose: We present a novel method to process kinematical data typically coming from measurements of joints. This method will be illustrated through two examples.

Methods: We adopt theoretical kinematics together with the principle of least action.

Studies on the systematics and taxonomy of the genus Hylaeus F. (8) Revision of the Afrotropic subgenus Hylaeus (Deranchylaeus) Bridwell (Hymenoptera: Anthophila, Colletidae).

The Afrotropic subgenus Deranchylaeus; of the colletid bee genus Hylaeus is revised for the first time on the basis of all the available type material. Here, 28 new synonymies were detected: Prosopis flaviscutum Alfken and Hylaeus graaffi Cockerell = H. curvicarinatus (Cameron); H.

A caveat concerning center of resistance.

The center of resistance is a concept in theoretical orthodontics used to describe tooth movement under loads. It is commonly used to qualitatively predict tooth movement without recourse to complex equations or simulations. We start with a survey of the historical origin of the technical term.