Resident and Fellow Perspectives on Family Planning and Building During Training.

Importance: Physicians, especially surgeons, delay family building, and face age-related complications of pregnancy.

Objective: To explore factors that are associated with family building decisions among residents and fellows and to understand their thoughts on accessing family building supports, workplace culture, and attitudes toward family planning.

Design, Setting, And Participants: This qualitative study was conducted from May to August 2022 at postgraduate training sites across Ontario, Canada.

Medical Students' Perspectives on Family Planning and Impact on Specialty Choice.

Importance: Physicians are known to delay childbearing compared with nonphysicians and to experience higher rates of age-related pregnancy complications. Delay of childbearing is more pronounced in surgical specialties, and family planning and building goals may influence specialty choice.

Objective: To assess medical students' perspectives on the development of family planning goals and the timing of family building within a medical career to elucidate how these perceptions impact their choice of specialty.

Patients' and providers' perspectives on the decision to undergo non-urgent egg freezing: a needs assessment.

Background: Previous research has demonstrated that patients have difficulty with the decision to undergo non-urgent egg freezing (EF). This study aimed to investigate the decisional difficulties and possible decisional support mechanisms for patients considering EF, and for their providers.

Methods: This qualitative study involved a needs assessment via individual interviews.

[Directive clinique n 437 : Diagnostic et prise en charge de l'adénomyose].

Objectif: Décrire les pratiques actuelles fondées sur des données probantes pour le diagnostic et la prise en charge de l'adénomyose.

Population Cible: Toutes les patientes en âge de procréer qui ont un utérus.

Options: Les options diagnostiques sont l'échographie endovaginale et l'imagerie par résonance magnétique.

Guideline No. 437: Diagnosis and Management of Adenomyosis.

Objective: To describe the current evidence-based diagnosis and management of adenomyosis.

Target Population: All patients with a uterus of reproductive age.

Options: Diagnostic options include transvaginal sonography and magnetic resonance imaging.

Patients' and providers' perspectives on non-urgent egg freezing decision-making: a thematic analysis.

Background: The decision to undergo non-urgent egg freezing (EF) is complex for patients and providers supporting them. Though prior studies have explored patient perspectives, no study has also included the separate perspectives of providers.

Methods: This qualitative study involved semi-structured individual interviews exploring the decision to undergo EF.

Pregnancy outcomes with donor oocyte embryos in patients diagnosed with adenomyosis using the Morphological Uterus Sonographic Assessment criteria.

Objective: To use the Morphological Uterus Sonographic Assessment (MUSA) criteria to evaluate the impact of adenomyosis on the live birth rate after donor egg embryo transfer.

Design: Retrospective cohort study.

Setting: Tertiary fertility care center.

Providers' perspectives on the reproductive decision-making of BRCA-positive women.

Background: Reproductive decision-making is difficult for BRCA-positive women. Our objective was to assess the complexities of decision-making and identify decisional supports for patients and providers when discussing reproductive options prior to risk-reducing salpingo-oophorectomy (RRSO).

Methods: This study was of qualitive design, using data collection via semi-structured interviews conducted from November 2018 to October 2020.

National Canadian Survey on the Management of Noneuploid Embryos.

Objective: To comprehensively describe current preimplantation genetic testing for aneuploidy (PGT-A) practices and management of non-euploid embryos in Canada.

Methods: This was a cross-sectional study utilizing an online survey distributed by email to all medical directors of fertility clinics with independent in vitro fertilization (IVF) embryology laboratories. The survey was designed to determine practice patterns regarding PGT-A usage; PGT-A reference laboratory, platform, and thresholds for classifying embryos; and management of embryos classified as mosaic, inconclusive, or aneuploid.

Comparison of three surgical approaches for staging lymphadenectomy in high-risk endometrial cancer.

Objective: To compare laparotomy, laparoscopy, and robotic surgical approaches to lymphadenectomy for high-risk endometrial cancer staging.

Methods: A retrospective cohort study enrolled patients who underwent surgery for pathologic high-risk endometrial carcinoma at the University Health Network, Toronto, Canada, between January 1, 2005 and December 31, 2013. The primary outcome, the median number of nodes retrieved, was compared based on surgical technique.

PGC-1α signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina.

Retinal ganglion cells (RGCs), used as a common model of central nervous system injury, are particularly vulnerable to metabolic and oxidative damage. However, molecular mechanisms underlying this sensitivity have not been determined in vivo. PGC-1α (encoded by PPARGC1A) regulates adaptive metabolism and oxidative stress responses in a tissue- and cell-specific manner.