A promising future for breast cancer therapy with hydroxamic acid-based histone deacetylase inhibitors.

Histone deacetylases (HDACs) play a critical role in chromatin remodelling and modulating the activity of various histone proteins. Aberrant HDAC functions has been related to the progression of breast cancer (BC), making HDAC inhibitors (HDACi) promising small-molecule therapeutics for its treatment. Hydroxamic acid (HA) is a significant pharmacophore due to its strong metal-chelating ability, HDAC inhibition properties, MMP inhibition abilities, and more.

Mixture effects of arsenic and chromium on erythrocytic nuclear abnormalities and expression of DNA repair, tumor suppressor and apoptotic genes in liver of zebrafish.

The present study investigated the individual and mixture effects of Arsenic (As) and Chromium (Cr) at their environmental concentrations in zebrafish (Danio rerio). After 15, 30 and 60 days of exposure, increased frequencies of erythrocytic nuclear abnormalities (ENAs) were noticed. After 60 days of exposure, DNA damage was observed in liver and base excision DNA repair (BER) and mismatch DNA repair (MMR) pathways were studied to know the cellular responses.

Acridine/Lewis Acid Complexes as Powerful Photocatalysts: A Combined Experimental and Mechanistic Study.

A class of generated Lewis acid (LA) activated acridine complexes is reported, which act as potent photochemical catalysts for the oxidation of a variety of protected secondary amines. Acridine/LA complexes exhibit tunable excited state reduction potentials ranging from +2.07 to 2.

Complete genome sequence of a Bangladesh-developed live-attenuated lumpy skin disease (LSD) vaccine strain.

Lumpy skin disease (LSD) in cattle is managed through live-attenuated vaccines. Bangladesh LSD vaccine was developed from LSD virus isolate Bangladesh LSD-29 by passaging 60 times in cell culture. Here, we report the complete genome sequence of Bangladesh LSD vaccine strain.

Triple train collision at Bahanaga Bazar: Disaster response and management: An observational study.

Background: Train collision accidents are tragic events associated with high mortality. The study aimed to comprehensively describe the clinical-epidemiological profile, disaster emergency response, and management following a train collision accident in Odisha, India.

Methods: This observational study was conducted by a tertiary care hospital in eastern India.

Chlorambucil Conjugation Enhances the Potency of Rituximab: Synthesis and Evaluation of the Novel [Lu]Lu-Labeled Rituximab-Chlorambucil Conjugate toward Therapy of Non-Hodgkin's Lymphoma.

In this study, a novel antibody-drug conjugate (ADC) consisting of Rituximab and Chlorambucil (Rituximab-CMB) was synthesized. The average number of drug molecules attached per Rituximab molecule was determined using MALDI-TOF mass spectrometry, revealing a range of 4-6 drug molecules per antibody. To further improve the therapeutic potential of the ADC, it was radiolabeled with the therapeutic radionuclide Lu via a DOTA chelator, achieving a final radiochemical purity of over 95%.

Photochemical Stabilization of Self-Assembled Spherical Nucleic Acids.

Oligonucleotide therapeutics, including antisense oligonucleotides and small interfering RNA, offer promising avenues for modulating the expression of disease-associated proteins. However, challenges such as nuclease degradation, poor cellular uptake, and unspecific targeting hinder their application. To overcome these obstacles, spherical nucleic acids have emerged as versatile tools for nucleic acid delivery in biomedical applications.

The Molecular Detection and Therapeutic Management of Pathogenic Infection in a Goat: A Case Report.

A 2-year-old female Assam Hill goat was presented with a clinical history of anorexia, fever, mild anemia, rough body coat, dehydration, tachycardia, dyspnea and swelling of palpable lymph nodes. Hematology revealed low hemoglobin, packed cell volume, red blood cell and thrombocyte count. Biochemical analysis showed increased serum concentration of alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine and urea in comparison to the normal reference range.

From Fragmented Facts to Unified Knowledge: Exploring Concept Mapping in Neuromuscular Physiology Among First-Year Medical Students.

Background First-year medical students may find it challenging to integrate complex physiological concepts, particularly neuromuscular physiology. While concept mapping has shown promise in medical education, its specific application in teaching intricate physiological mechanisms still needs to be explored. With this background, the objective of the study was to assess the feasibility of using concept mapping among first-year medical students and to explore the perception of students about concept mapping as an educational tool.

Predicting age at first calving of dairy breed calves using whale optimization-based ensemble learning framework.

Dairy product requirement and the demand-supply gap of milk in Ethiopia have been increasing at an alarming rate due to various factors such as shortage of animal's feeds, feed staffs, feed costs, and poor genetic merits of the local breeds of the country. This problem can be lessened by selecting best breed and modern animal breeding facilities, which require technologies like big data analysis and machine learning. In this study, a prediction model that can predict age at first calving of weaned calves based on their pre-weaning and weaning parameters, including dam's parity number, season of calving, birth weight, pre-weaning health status, pre-weaning average daily weight gain (ADG), weaning age and weaning weight is developed.

Predicting recovery in patients with mild traumatic brain injury and a normal CT using serum biomarkers and diffusion tensor imaging (CENTER-TBI): an observational cohort study.

Background: Even patients with normal computed tomography (CT) head imaging may experience persistent symptoms for months to years after mild traumatic brain injury (mTBI). There is currently no good way to predict recovery and triage patients who may benefit from early follow-up and targeted intervention. We aimed to assess if existing prognostic models can be improved by serum biomarkers or diffusion tensor imaging metrics (DTI) from MRI, and if serum biomarkers can identify patients for DTI.

Zwitterionic, Stimuli-Responsive Liposomes for Curcumin Drug Delivery: Enhancing M2 Macrophage Polarization and Reducing Oxidative Stress through Enzyme-Specific and Hyperthermia-Triggered Release.

A zwitterionic, stimuli-responsive liposomal system was meticulously designed for the precise and controlled delivery of curcumin, leveraging enzyme-specific and hyperthermic stimuli to enhance therapeutic outcomes. This platform is specifically engineered to release curcumin in response to , an enzyme that degrades phospholipids, enabling highly targeted and site-specific drug release. Mild hyperthermia (40 °C) further enhances membrane permeability and activates thermosensitive carriers, optimizing drug delivery.

Evaluating the Impact of Adjustable- and Fixed-Loop Femoral Endobuttons on Intraoperative Surgeon Satisfaction and Postoperative Patient Functional Outcomes in Anterior Cruciate Ligament (ACL) Reconstruction.

Introduction: This study aims to evaluate the effects of adjustable- and fixed-loop femoral endobuttons on intraoperative surgeon satisfaction and postoperative patient functional outcomes in anterior cruciate ligament (ACL) reconstruction. The use of cortical suspensory devices, either fixed-loop or adjustable-loop, is common in ACL reconstruction surgeries for femoral tunnel fixation. Fixed-loop devices, although effective, often require additional tunnel drilling, potentially leading to tunnel widening.

The structure-dynamics feedback mechanism governs the glassy dynamics in epithelial monolayers.

The glass-like slow dynamics in confluent epithelial monolayers is crucial for wound healing, embryogenesis, cancer progression, Experiments have indicated several unusual properties in these systems. Unlike ordinary glasses, the glassiness in cellular systems strongly correlates with their static properties and is sub-Arrhenius. These results imply that the slow dynamics in epithelial monolayers is either not glassy or the underlying mechanism is different from ordinary glasses.

Circulating microRNAs in Body Fluid: "Fingerprint" RNA Snippets Deeply Impact Reproductive Biology.

Circulating miRNAs (C-miRNAs) occuring in a cell-free form within body fluids and other extracellular environments have garnered attention in recent times. They offer deeper insight into various physiological and pathological processes which include reproductive health. This review delves into their diagnostic potential across a spectrum of reproductive disorders, including conditions affecting ovarian function, male infertility and post pregnancy issues.

fabricated gold nanostars on hydrogel beads as photo-oxidase mimics for rapid and sustainable POCT of uric acid.

Synthetic enzyme mimics surpass their natural counterparts in terms of stability, efficiency, and cost-effectiveness, making them highly valuable for catalytic applications. Gold nanomaterials, particularly gold nanostars, have emerged as promising enzyme mimetic nanocatalysts due to their enhanced light interaction and superior catalytic efficiency. In this study, gold nanostars grown on the surface of core-shell hydrogel beads exhibited specific oxidase-like activity when exposed to light.

Peptide-based nanomaterials and their diverse applications.

The supramolecular self-assembly of peptides offers a promising avenue for both materials science and biological applications. Peptides have garnered significant attention in molecular self-assembly, forming diverse nanostructures with α-helix, β-sheet, and random coil conformations. These self-assembly processes are primarily driven by the amphiphilic nature of peptides and stabilized by non-covalent interactions, leading to complex nanoarchitectures responsive to environmental stimuli.

Corrigendum: The immunomodulatory impact of naturally derived neem leaf glycoprotein on the initiation progression model of 4NQO induced murine oral carcinogenesis: a preclinical study.

[This corrects the article DOI: 10.3389/fimmu.2024.

Toxicity evaluation and degradation of cypermethrin-contaminated soil using biochar and Bacillus cereus amendments.

Cypermethrin (Cyp), a persistent synthetic pyrethroid insecticide widely used for insect control. The persistence of Cyp creates toxicity to both humans and the environment This study investigates biochar and Bacillus cereus distinct and collective effects on Cyp -contaminated soil during a 90-day incubation. This study also investigates the effects of different concentrations of Cyp (50, 100, ,500 to 1000 mg kg) on soil physicochemical and biological activities during a 90-day incubation period.

Evaluating anti-inflammatory and anti-oxidative potentialities of the chloroform fraction of Asparagus racemosus roots against cisplatin induced acute kidney injury.

Ethnopharmacological Relevance: Acute kidney injury (AKI), a global public health concern that increases the risk of death, end-stage renal disease, and prolonged hospital admissions. As of this point, supportive measures like fluid resuscitation and replacement therapy for renal failure are the only treatments available for treating AKI. Asparagus racemosus (AR) also known as Shatavari, belongs to family Liliaceae and is considered exceptional in Ayurvedic medicine due to its versatility in treating and preventing a variety of illnesses.