Superconductors, orbital magnets and correlated states in magic-angle bilayer graphene.

Superconductivity can occur under conditions approaching broken-symmetry parent states. In bilayer graphene, the twisting of one layer with respect to the other at 'magic' twist angles of around 1 degree leads to the emergence of ultra-flat moiré superlattice minibands. Such bands are a rich and highly tunable source of strong-correlation physics, notably superconductivity, which emerges close to interaction-induced insulating states.

First Observation of an Attractive Interaction between a Proton and a Cascade Baryon.

This Letter presents the first experimental observation of the attractive strong interaction between a proton and a multistrange baryon (hyperon) Ξ^{-}. The result is extracted from two-particle correlations of combined p-Ξ^{-}⊕p[over ¯]-Ξ[over ¯]^{+} pairs measured in p-Pb collisions at sqrt[s_{NN}]=5.02  TeV at the LHC with ALICE.

Looking for medium-term conservation and development impacts of community management agreements in Uganda's Rwenzori Mountains National Park.

We evaluate the impact of collaborative management agreements (CMAs) designed to protect forests and raise incomes for smallholders living adjacent to Rwenzori Mountains National Park (RMNP), Uganda. We use a quasi-experimental study design to estimate changes in several income measures, as well as land cover using three waves (2003, 2007, and 2012) of household survey and remote sensing data. Overall, we find no significant impact of CMAs on any of our income measures.

Combining ERBB family and MET inhibitors is an effective therapeutic strategy in cutaneous malignant melanoma independent of BRAF/NRAS mutation status.

Current treatment modalities for disseminated cutaneous malignant melanoma (CMM) improve survival; however, relapses are common. A number of receptor tyrosine kinases (RTKs) including EGFR and MET have been reported to be involved in CMM metastasis and in the development of resistance to therapy, targeting the mitogen-activated protein kinase (MAPK pathway). IHC analysis showed that patients with higher MET protein expression had a significantly shorter overall survival.

Diet and nutrition: An important risk factor in leprosy.

Leprosy, once considered as poor man's disease may cause severe neurological complications and physical disabilities. Classification of leprosy depends upon the cell mediated and humoral immune responses of the host, from tuberculoid to lepromatous stage. Current therapy to prevent the disease is not only very lengthy but also consists of expensive multiple antibiotics in combination.

Glamour, expression, and consequences of tattoos in radiation treatment.

It is estimated that approximately 24% of the US population has at least one tattoo. However, tattoo ink ingredients include heavy metals (high atomic number Z) that are not regulated, which can cause skin reactions. This study investigates the dosimetric effects in surface dose due to high-Z elements in tattoo ink under electron beam irradiation.

Biological Indices Evaluation of Various Treatment Techniques for Left-Sided Breast Treatment.

Purpose: To compare dose to organs at risk (OARs) and biological evaluation using normal tissue complication probability (NTCP) for left-sided breast radiation therapy in 4 techniques: supine free breathing (SFB), supine deep inspiration breath hold (SDIBH), prone free breathing (PFB), and prone deep inspiration breath hold (PDIBH).

Methods And Materials: Twenty-five patients with left-sided breast cancer suitable for this study underwent a computed tomography scan using SFB, SDIBH, PFB, and PDIBH. One radiation oncologist contoured the planning target volume and OAR (cardiac components).

svtools: population-scale analysis of structural variation.

Summary: Large-scale human genetics studies are now employing whole genome sequencing with the goal of conducting comprehensive trait mapping analyses of all forms of genome variation. However, methods for structural variation (SV) analysis have lagged far behind those for smaller scale variants, and there is an urgent need to develop more efficient tools that scale to the size of human populations. Here, we present a fast and highly scalable software toolkit (svtools) and cloud-based pipeline for assembling high quality SV maps-including deletions, duplications, mobile element insertions, inversions and other rearrangements-in many thousands of human genomes.

Deep convolutional neural network for reduction of contrast-enhanced region on CT images.

This study aims to produce non-contrast computed tomography (CT) images using a deep convolutional neural network (CNN) for imaging. Twenty-nine patients were selected. CT images were acquired without and with a contrast enhancement medium.

A multifaceted approach for analyzing complex phenotypic data in rodent models of autism.

Autism (MIM 209850) is a multifactorial disorder with a broad clinical presentation. A number of high-confidence ASD risk genes are known; however, the contribution of non-genetic environmental factors towards ASD remains largely uncertain. Here, we present a bioinformatics resource of genetic and induced models of ASD developed using a shared annotation platform.

Characterization of the plastic scintillation detector Exradin W2 for small field dosimetry.

Purpose: Small field dosimetry has been an active area of research for over a decade. It is now known that large dosimetric errors can be introduced if proper detectors or correction factors are not used. The International Atomic Energy Agency (IAEA) through the technical report series No.

Azimuthal Anisotropy of Heavy-Flavor Decay Electrons in p-Pb Collisions at sqrt[s_{NN}]=5.02 TeV.

Angular correlations between heavy-flavor decay electrons and charged particles at midrapidity (|η|<0.8) are measured in p-Pb collisions at sqrt[s_{NN}]=5.02  TeV.

Visible-Light-Activated Divergent Reactivity of Dienones: Dimerization in Neat Conditions and Regioselective E to Z Isomerization in the Solvent.

2,4-Dienones undergo visible-light-promoted, photocatalyst-free dimerization in neat conditions to provide cyclohexene derivatives stereoselectively through cascade rearrangement pathways, whereas regioselective E → Z isomerization of the more dienophilic double bond takes place exclusively in nitromethane. On the basis of intermediate isolation and computational DFT studies, the dimerization reaction is proposed to proceed via s-trans to s-cis isomerization/regioselective E → Z isomerization/Diels-Alder cycloaddition.

Geometric morphometric analysis in female freshwater crabs of Sarawak (Borneo) permits addressing taxonomy-related problems.

The taxonomy of freshwater crabs requires a paradigm change in methodological approaches, particularly in investigations that use morphological techniques. The traditional morphometric approach (two-dimensional measurements) tends to be inappropriate for the identification of freshwater crabs due to their variable external morphology and lack of gonopods (conventionally used for the identification of male crabs) in females. In this study, we explore the potential use of the geometric morphometric technique for identification of female freshwater crabs, and identify taxonomic key characteristics of species.

Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy.

The biological effectiveness of proton beams relative to photon beams in radiation therapy has been taken to be 1.1 throughout the history of proton therapy. While potentially appropriate as an average value, actual relative biological effectiveness (RBE) values may differ.

Early Adoption of an Improved Household Energy System in Urban Rwanda.

Cooking with solid fuels and inefficient cookstoves has adverse consequences for health, environment, and human well-being. Despite the promise of improved cookstoves to reduce these impacts, adoption rates are relatively low. Using a 2-wave sample of 144 households from the baseline and first midline of an ongoing 4-year randomized controlled trial in Rwanda, we analyze the drivers and associations of early adoption of a household energy intervention marketed by a private sector firm.

CO fluxes from aquaculture ponds of a tropical wetland: Potential of multiple lime treatment in reduction of CO emission.

Partial pressure of CO in water [pCO(water)] and air-water CO flux were estimated in two aquaculture ponds (one received no lime treatment (NTP) and in the other lime treatment was performed (LTP) four times a year) every month throughout an annual cycle, situated in East Kolkata Wetlands, a Ramsar Site in eastern India. It was hypothesized that lime treatment can potentially lower the pCO(water) in aquaculture ponds and hence make these aquatic bodies sinks for CO. The results portrayed that NTP acted as a source of CO throughout the year (annual mean: 1929 ± 1397 μmol m h), whereas, LTP acted as CO sinks post lime addition (monthly mean ranged from -366 ± 16 to -449 ± 32 μmol m h), though the effect of lime addition was found to diminish by the next month and it acted as source for CO in the months when no lime treatment was done (LTP annual mean: 1010 ± 1617 μmol m h).

An effective method to reduce the interplay effects between respiratory motion and a uniform scanning proton beam irradiation for liver tumors: A case study.

Purpose: For scanning particle beam therapy, interference between scanning patterns and interfield organ motion may result in suboptimal dose within target volume. In this study, we developed a simple offline correction technique for uniform scanning proton beam (USPB) delivery to compensate for the interplay between scanning patterns and respiratory motion and demonstrate the effectiveness of our technique in treating liver cancer.

Methods: The computed tomography (CT) and respiration data of two patients who had received stereotactic body radiotherapy for hepatocellular carcinoma were used.

Haemodynamic effects of pharmacologic stress with adenosine in patients with left ventricular systolic dysfunction.

Background: In patients with heart failure, downregulation of adenosine receptor gene expression and impaired adenosine-related signal transduction may result in a diminished response to adenosine. This may have implications for cardiac stress testing. We evaluated the haemodynamic response to intravenous adenosine in patients with left ventricular systolic dysfunction (LVSD) undergoing stress cardiovascular magnetic resonance imaging (CMR).

A 'burning opportunity' for human rights: using human rights as a catalyst for policies to mitigate the health risk of household air pollution.

With over 3 billion people dependent on traditional cooking and heating technologies, efforts to address the health burden of exposure to household air pollution (HAP), as well as other sociodemographic impacts associated with energy poverty, are central to sustainable development objectives. Yet despite overwhelming scientific consensus on the health burden of HAP exposure, particularly harms to impoverished women and children in developing countries, advocates currently lack a human rights framework to mitigate HAP exposure through improved access to cleaner household energy systems. This article examines the role of human rights in framing state obligations to mitigate HAP exposure, supporting environmental health for the most vulnerable through intersectional obligations across the human right to health, the collective right to development, and women's and children's rights.

Implementation and scale-up of a biomass pellet and improved cookstove enterprise in Rwanda.

This paper reviews the experience of a for-profit firm in Rwanda promoting biomass pellets and a fan micro-gasification improved cookstove as a clean cooking alternative to charcoal. Consumers purchase locally produced biomass pellets and receive the improved cookstove on a lease basis. The cost of the pellets and stove(s) is lower than the cost of cooking with charcoal in the urban setting where our study takes place.

Evolution of nuchal glands, unusual defensive organs of Asian natricine snakes (Serpentes: Colubridae), inferred from a molecular phylogeny.

A large body of evidence indicates that evolutionary innovations of novel organs have facilitated the subsequent diversification of species. Investigation of the evolutionary history of such organs should provide important clues for understanding the basis for species diversification. An Asian natricine snake, , possesses a series of unusual organs, called nuchal glands, which contain cardiotonic steroid toxins known as bufadienolides.

Role and future of MRI in radiation oncology.

Technical innovations and developments in areas such as disease localization, dose calculation algorithms, motion management and dose delivery technologies have revolutionized radiation therapy resulting in improved patient care with superior outcomes. A consequence of the ability to design and accurately deliver complex radiation fields is the need for improved target visualization through imaging. While CT imaging has been the standard of care for more than three decades, the superior soft tissue contrast afforded by MR has resulted in the adoption of this technology in radiation therapy.