Design of Na -Selective Fluorescent Probes: A Systematic Study of the Na -Complex Stability and the Na /K Selectivity in Acetonitrile and Water.

There is a tremendous demand for highly Na -selective fluoroionophores to monitor the top analyte Na in life science. Here, we report a systematic route to develop highly Na /K selective fluorescent probes. Thus, we synthesized a set of fluoroionophores 1, 3, 4, 5, 8 and 9 (see Scheme ) to investigate the Na /K selectivity and Na - complex stability in CH CN and H O.