Publications by authors named "Darya A Denisova"
EVs are involved in local and distant intercellular communication and play a vital role in cancer development. Since EVs have been found in almost all body fluids, there are currently active attempts for their application in liquid diagnostics. Blood is the most commonly used source of EVs for the screening of cancer markers, although the percentage of tumor-derived EVs in the blood is extremely low.
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- Extracellular vesicles (EVs), particularly exosomes, play a crucial role in cell communication and are emerging as valuable indicators for cancer diagnosis due to their molecular similarities to parent cells and stability of their bioactive cargo.
- Uterine aspirate (UA) samples from epithelial ovarian cancer (EOC) patients and healthy donors can be analyzed for EVs, which are more abundant in this localized fluid than in other body fluids.
- Profiling of small RNAs from these UA-derived EVs revealed significant differences in miRNA expression between EOC patients and healthy individuals, suggesting their potential as diagnostic markers for gynecological cancers.