Publications by authors named "Darshit Thakar"
Article Synopsis
- There is a variation in white matter hyperintensity (WMH) levels among cognitively normal individuals, with some showing significant WMH and others not, even at the same chronological age.
- A study using MRI data from different age groups (50-80+) assessed brain structures to differentiate between cognitively normal (CN), cognitively impaired (CI), and those with Alzheimer's-related cognitive impairment (CI-AD), revealing significant gray matter and white matter loss in early age groups.
- The research determined that three key brain measurements—total brain volume, cerebrospinal fluid (CSF), and WMH volume—can effectively distinguish between cognitive status, while a new index called 'Brain Age' indicates neuroanatomic health, showing
Biological aging can be described as accumulative, prolonged metabolic stress and is the major risk factor for cognitive decline and Alzheimer's disease (AD). Recently, we identified and described a quinone reductase 2 (QR2) pathway in the brain, in which QR2 acts as a removable memory constraint and metabolic buffer within neurons. QR2 becomes overexpressed with age, and it is possibly a novel contributing factor to age-related metabolic stress and cognitive deficit.
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