Publications by authors named "Darshil R Patel"
Eukaryotic cells continuously experience DNA damage that can perturb key molecular processes like DNA replication. DNA replication forks that encounter DNA lesions typically slow and may stall, which can lead to highly detrimental fork collapse if appropriate protective measures are not executed. Stabilization and protection of stalled replication forks ensures the possibility of effective fork restart and prevents genomic instability.
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- The RAD9A-HUS1-RAD1 (9-1-1) complex is essential for DNA damage signaling and repair, with a specific focus on the HUS1 protein's functional residues.
- Key findings show that certain residues within HUS1 are crucial for its assembly, DNA binding, and the ability to signal for DNA repair processes, particularly under genotoxic stress.
- The research suggests that distinct regions of HUS1 play different roles: while some are vital for chromatin localization and signaling, others are necessary for interacting with proteins like MYH, highlighting the complex's multifaceted role in maintaining genomic integrity.