Publications by authors named "Darshan Saieesh"
Author Correction: Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma.
Sujith Kumar Pulukool Sai Krishna Srimadh Bhagavatham Vishnu Kannan Piruthivi Sukumar Rajesh Babu Dandamudi Darshan Saieesh
Sci Rep
September 2021
Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma.
Sujith Kumar Pulukool Sai Krishna Srimadh Bhagavatham Vishnu Kannan Piruthivi Sukumar Rajesh Babu Dandamudi Darshan Saieesh
Sci Rep
May 2021
Article Synopsis
- Glaucoma, particularly primary open angle glaucoma (POAG), is a leading cause of blindness, characterized by high intraocular pressure and nitric oxide synthase dysfunction.
- Clinical analyses revealed increased levels of ATP in aqueous humor, elevated cytokines in plasma, and significant changes in 21 metabolites, including dimethylarginine (DMAG), highlighting metabolic alterations associated with POAG.
- Research using N9 microglial cells showed that DMAG and ATP play key roles in modulating purinergic signaling, inflammation, and tryptophan metabolism, suggesting potential avenues for therapeutic strategies in managing POAG.