Search for novel ATP4 inhibitors from the MMV Pandemic Response Box through a virtual screening approach.

Owing to its life cycle involving multiple hosts and species-specific biological complexities, a vaccine against , the causative agent of remains elusive. This makes chemotherapy the only viable means to address the clinical manifestations and spread of this deadly disease. However, rapid surge in antimalarial resistance poses significant challenges to our efforts to eliminate since the best drug available to-date; Artemisinin and its combinations are also rapidly losing efficacy.