Publications by authors named "Darryl B Dunn"
Article Synopsis
- The study investigates the role of the chemokine CCL21 and its receptor CCR7 in the chemotactic-metastasis of melanoma, where tumor cells preferentially grow towards areas with abundant lymphatic endothelial cells (LECs).
- Researchers conducted in vivo experiments with melanoma cells that over-express CCR7, showing that these cells have a significantly increased ability to grow towards LECs compared to non-metastatic controls.
- The findings indicate that the presence of CCR7 allows melanoma cells to recognize and invade lymphatic regions, supporting the hypothesis that chemotactic factors play a crucial role in tumor spread.
Cancer and dendritic cells recognize and migrate toward chemokines secreted from lymphatics and use this mechanism to invade the lymphatic system, and cancer cells metastasize through it. The lymphatic-secreted chemokine ligand CCL21 has been identified as a key regulatory molecule in the switch to a metastatic phenotype in melanoma and breast cancer cells. However, it is not known whether CCL21 inhibition is a potential therapeutic strategy for inhibition of metastasis.
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