Publications by authors named "Darryl B A Dunn"
Article Synopsis
- The study investigates the role of the chemokine CCL21 and its receptor CCR7 in the chemotactic-metastasis of melanoma, where tumor cells preferentially grow towards areas with abundant lymphatic endothelial cells (LECs).
- Researchers conducted in vivo experiments with melanoma cells that over-express CCR7, showing that these cells have a significantly increased ability to grow towards LECs compared to non-metastatic controls.
- The findings indicate that the presence of CCR7 allows melanoma cells to recognize and invade lymphatic regions, supporting the hypothesis that chemotactic factors play a crucial role in tumor spread.