Publications by authors named "Darrin R Uecker"
Article Synopsis
- This study examines a new catheter-based technique using nanosecond pulsed electric fields for cardiac ablation in pigs, focusing on its effectiveness at targeting both cell membranes and intracellular organelles.
- The research involved 25 pigs, assessing the impact of different ablation durations (low-dose and high-dose) on various heart sites, with evaluations conducted over various survival periods.
- Results showed that all targeted veins were successfully isolated, lesion depth was significant, and while there were some transient effects on the phrenic nerve and esophagus, most animals healed well over time with minimal long-term damage.
Effects of Pulsed Electric Fields on the Coronary Arteries in Swine.
Circ Arrhythm Electrophysiol
October 2022
Background: Previous animal studies have shown no significant vascular injury from pulsed electrical field (PEF) ablation. We sought to assess the effect of PEF on swine coronary arteries.
Methods: We performed intracoronary and epicardial (near the coronary artery) PEF ablations in swine pretreated with dual antiplatelet and antiarrhythmic therapy.