Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs.

Spermatozoa harbour a complex and environment-sensitive pool of small non-coding RNAs (sncRNAs), which influences offspring development and adult phenotypes. Whether spermatozoa in the epididymis are directly susceptible to environmental cues is not fully understood. Here we used two distinct paradigms of preconception acute high-fat diet to dissect epididymal versus testicular contributions to the sperm sncRNA pool and offspring health.

Synthesis of cerium, zirconium, and copper doped zinc oxide nanoparticles as potential biomaterials for tissue engineering applications.

A novel eco-friendly high throughput continuous hydrothermal flow system was used to synthesise phase pure ZnO and doped ZnO in order to explore their properties for tissue engineering applications. Cerium, zirconium, and copper were introduced as dopants during flow synthesis of ZnO nanoparticles, Zirconium doped ZnO were successfully synthesised, however secondary phases of CeO and CuO were detected in X-ray diffraction (XRD). The nanoparticles were characterised using X-ray diffraction, Brunauer-Emmett-Teller (BET), Dynamic Light scattering Measurements, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and RAMAN spectroscopy was used to evaluate physical, chemical, and structural properties.

Palladium Encapsulated by an Oxygen-Saturated TiO Overlayer for Low-Temperature SO -Tolerant Catalysis during CO Oxidation.

The development of oxidation catalysts that are resistant to sulfur poisoning is crucial for extending the lifespan of catalysts in real-working conditions. Herein, we describe the design and synthesis of oxide-metal interaction (OMI) catalyst under oxidative atmospheres. By using organic coated TiO , an oxide/metal inverse catalyst with non-classical oxygen-saturated TiO overlayers were obtained at relatively low temperature.

Guidelines of care for the management of atopic dermatitis in adults with topical therapies.

Background: New evidence has emerged since the 2014 guidelines that further informs the management of atopic dermatitis (AD) with topical therapies. These guidelines update the 2014 recommendations for management of AD with topical therapies.

Objective: To provide evidence-based recommendations related to management of AD in adults using topical treatments.

Executive summary: American Academy of Dermatology guidelines of care for the management of atopic dermatitis in adults with topical therapies.

These guidelines update the 2014 recommendations for management of atopic dermatitis in adults with topical therapies. A multidisciplinary workgroup employed best practices for guideline development, including a systematic review of the evidence and application of the Grading of Recommendations, Assessment, Development, and Evaluation approach for assessing the certainty of the evidence and formulating and grading recommendations. The evidence on atopic dermatitis treatment supported strong recommendations for the use of nonprescription moisturizers, topical calcineurin inhibitors, topical corticosteroids, and topical PDE-4 and JAK inhibitors.

Probing the Dependence of Long-Range, Four-Atom Interactions on Intermolecular Orientation. 4. The Dissociation Dynamics of H/D···ICl(B,'=3) and the Observation of Efficient Vibrational-Rotational Energy Transfer.

The vibrational predissociation dynamics of H/D···ICl(B,'=3) complexes containing both - and -hydrogen prepared in different intermolecular vibrational levels were investigated. The Δ = -1 ICl(B, = 2,) rotational product-state distributions measured for excitation to the lowest-energy T-shaped levels of these complexes are mostly bimodal. The rotational distributions measured for excitation of the H···ICl(B,'=3) complexes are colder than those of the D···ICl(B,'=3) complexes, and there are only slight differences between those measured for the - and -hydrogen containing complexes.

Tuneable magnetic nanocomposites for remote self-healing.

When polymer composites containing magnetic nanoparticles (MNPs) are exposed to an alternating magnetic field, heat is generated to melt the surrounding polymer locally, partially filling voids across any cracks or deformities. Such materials are of interest for structural applications; however, structural polymers with high melting temperatures pose the challenge of generating high localised temperatures enabling self-healing. A method to prepare a multiferroic-Polyamide 6 (PA6) nanocomposite with tuneable magnetocaloric properties is reported.

Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing.

Cardiosphere-derived cells (CDCs) generated from human cardiac biopsies have been shown to have disease-modifying bioactivity in clinical trials. Paradoxically, CDCs' cellular origin in the heart remains elusive. We studied the molecular identity of CDCs using single-cell RNA sequencing (sc-RNAseq) in comparison to cardiac non-myocyte and non-hematopoietic cells (cardiac fibroblasts/CFs, smooth muscle cells/SMCs and endothelial cells/ECs).

American Academy of Dermatology Guidelines: Awareness of comorbidities associated with atopic dermatitis in adults.

Background: Studies found associations between atopic dermatitis (AD) and various comorbidities.

Objective: To appraise evidence of the association between AD and comorbidities among adults.

Methods: Our multidisciplinary work group conducted a systematic review of the association between AD and selected comorbidities.

Cycling Rate-Induced Spatially-Resolved Heterogeneities in Commercial Cylindrical Li-Ion Batteries.

Synchrotron high-energy X-ray diffraction computed tomography has been employed to investigate, for the first time, commercial cylindrical Li-ion batteries electrochemically cycled over the two cycling rates of C/2 and C/20. This technique yields maps of the crystalline components and chemical species as a cross-section of the cell with high spatiotemporal resolution (550 × 550 images with 20 × 20 × 3 µm voxel size in ca. 1 h).

Vibrational predissociation intramolecular vibrational energy redistribution (IVR) in rare gas⋯dihalogen complexes: IVR identified in Ar⋯I(B, ') using velocity-map imaging.

The competition between multiple pathways sampled during the energetic relaxation of excited molecules can be difficult to experimentally decipher. The rare gas···dihalogen van der Waals complexes have remained key systems for exploring the competition between relaxation pathways, such as intramolecular vibrational energy redistribution (IVR) and vibrational predissociation (VP). As these mechanisms can yield the same products, the relaxation pathways traversed are often deduced from the excitation spectra or product-state distributions.

Quality management systems in Aboriginal Community Controlled Health Services: a review of the literature.

Background: A national accreditation policy for the Australian primary healthcare (PHC) system was initiated in 2008. While certification standards are mandatory, little is known about their effects on the efficiency and sustainability of organisations, particularly in the Aboriginal Community Controlled Health Service (ACCHS) sector.

Aim: The literature review aims to answer the following: to what extent does the implementation of the International Organisation for Standardization 9001:2008 quality management system (QMS) facilitate efficiency and sustainability in the ACCHS sector?

Methods: Thematic analysis of peer-reviewed and grey literature was undertaken from Australia and New Zealand PHC sector with a focus on First Nations people.

Control of crystal size tailors the electrochemical performance of α-VO as a Mg intercalation host.

α-VO has been extensively explored as a Mg intercalation host with potential as a battery cathode, offering high theoretical capacities and potentials vs. Mg/Mg. However, large voltage hysteresis is observed with Mg insertion and extraction, introducing significant and unacceptable round-trip energy losses with cycling.

Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors.

Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes.

Enhancing bifunctional catalytic activity of cobalt-nickel sulfide spinel nanocatalysts through transition metal doping and its application in secondary zinc-air batteries.

Developing large-scale and high-performance OER (oxygen evolution reaction) and ORR (oxygen reduction reaction) catalysts have been a challenge for commercializing secondary zinc-air batteries. In this work, transition metal-doped cobalt-nickel sulfide spinels are directly produced a continuous hydrothermal flow synthesis (CHFS) approach. The nanosized cobalt-nickel sulfides are doped with Ag, Fe, Mn, Cr, V, and Ti and evaluated as bifunctional OER and ORR catalyst for Zn-air battery application.

High Throughput Synthesis and Screening of Oxygen Reduction Catalysts in the TiO ( = Ca, Sr, Ba) Perovskite Phase Diagram.

A library of 66 perovskite BaSrCaTiO ( + + = 1) samples (ca. three grams per sample) was made in ca. 14 h using a high-throughput continuous hydrothermal flow synthesis system.

Enhanced charge storage of nanometric ζ-VO in Mg electrolytes.

V2O5 is of interest as a Mg intercalation electrode material for Mg batteries, both in its thermodynamically stable layered polymorph (α-V2O5) and in its metastable tunnel structure (ζ-V2O5). However, such oxide cathodes typically display poor Mg insertion/removal kinetics, with large voltage hysteresis. Herein, we report the synthesis and evaluation of nanosized (ca.

Probing Mg Intercalation in the Tetragonal Tungsten Bronze Framework VNbO.

While commercial Li-ion batteries offer the highest energy densities of current rechargeable battery technologies, their energy storage limit has almost been achieved. Therefore, there is considerable interest in Mg batteries, which could offer increased energy densities in comparison to Li-ion batteries if a high-voltage electrode material, such as a transition-metal oxide, can be developed. However, there are currently very few oxide materials which have demonstrated reversible and efficient Mg insertion and extraction at high voltages; this is thought to be due to poor Mg diffusion kinetics within the oxide structural framework.

Aerosol-assisted route to low-E transparent conductive gallium-doped zinc oxide coatings from pre-organized and halogen-free precursor.

Thermal control in low-emission windows is achieved by the application of glazings, which are simultaneously optically transparent in the visible and reflective in the near-infrared (IR). This phenomenon is characteristic of coatings with wide optical band gaps that have high enough charge carrier concentrations for the material to interact with electromagnetic radiation in the IR region. While conventional low-E coatings are composed of sandwiched structures of oxides and thin Ag films or of fluorinated SnO coatings, ZnO-based glazing offers an environmentally stable and economical alternative with competitive optoelectronic properties.

iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis.

Biofluids contain various circulating cell-free RNAs (ccfRNAs). The composition of these ccfRNAs varies among biofluids. They constitute tantalizing biomarker candidates for several pathologies and have been demonstrated to be mediators of cellular communication.

Application of Photo-Electrochemically Generated Hydrogen with Fuel Cell Based Micro-Combined Heat and Power: A Dynamic System Modelling Study.

Photo-electrochemical (PEC) hydrogen generation is a promising technology and alternative to photovoltaic (PV)-electrolyser combined systems. Since there are no commercially available PEC cells and very limited field trials, a computer simulation was used to assess the efficacy of the approach for different domestic applications. Three mathematical models were used to obtain a view on how PEC generated hydrogen is able to cover demands for a representative dwelling.

Tailoring the electrochemical activity of magnesium chromium oxide towards Mg batteries through control of size and crystal structure.

Chromium oxides with the spinel structure have been predicted to be promising high voltage cathode materials in magnesium batteries. Perennial challenges involving the mobility of Mg2+ and reaction kinetics can be circumvented by nano-sizing the materials in order to reduce diffusion distances, and by using elevated temperatures to overcome activation energy barriers. Herein, ordered 7 nm crystals of spinel-type MgCr2O4 were synthesized by a conventional batch hydrothermal method.