Publications by authors named "Darpan Kayastha"

Article Synopsis
  • * A life cycle assessment (LCA) of ESS reveals that single-use instruments are responsible for the majority (89%‒96%) of environmental impacts, while using multi-use items could reduce energy consumption and global warming potential by 25%‒33%.
  • * Waste-to-energy incineration is preferred for managing end-of-life waste from single-use items, as it recovers energy but leads to higher greenhouse gas emissions, highlighting the need for a balanced approach to waste management.
View Article and Find Full Text PDF
Article Synopsis
  • Dupilumab is a medication that focuses on Th2-related inflammation to help lessen symptoms in patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).
  • Although uncommon, using Dupilumab can lead to certain infections, including those caused by viruses, worms (helminths), and possibly amoebas.
  • The aim of Dupilumab is to improve health outcomes for individuals suffering from this specific type of nasal condition.
View Article and Find Full Text PDF

Objectives: Antithrombotic therapies, comprised of both anticoagulant and antiplatelet agents, are routinely paused prior to endoscopic sinus surgery (ESS) to reduce the risk of perioperative hemorrhage. At present, no clear guidelines exist to guide otolaryngologists on when to resume these agents after ESS. Our goal was to systematically review the existing literature related to this topic.

View Article and Find Full Text PDF

Objective: To quantify the environmental impact of standard direct laryngoscopy surgery and model the environmental benefit of three feasible alternative scenarios that meet safe decontamination reprocessing requirements.

Study Design: This is a life cycle assessment (LCA) modeling study.

Setting: Yale-New Haven Hospital (YNHH), a 1541-bed tertiary medical center in New Haven, Connecticut, USA.

View Article and Find Full Text PDF

3D printing for virtual surgical planning of nasoseptal flap skull base reconstruction is a viable approach. Results indicate improved mucosal preservation but further research is needed to define impact on quality of life.

View Article and Find Full Text PDF

Bioabsorbable implants (eg, Latera) have recently been approved for addressing nasal valve collapse. The purpose of this study is to summarize adverse events and treatment sequelae associated with bioabsorbable nasal implants queried in the Manufacturer and User Facility Device Experience (MAUDE) database. Of the 26 device reports entered between March 2017 and April 2022, the most frequently reported complications included abscess (n = 13) and implant protrusion (n = 5).

View Article and Find Full Text PDF

Objectives: To analyze trends in billing patterns, Medicare reimbursement, and practice-setting for otolaryngologists (ORLs) and other provider types performing in-office cerumen removal.

Methods: This retrospective study included data on Medicare-billing providers from the Medicare Part B: Provider Utilization and Payment Datafiles (2012-2018). Number of providers performing in-office cerumen removal, total sums and medians for Medicare reimbursements and services, and services per patient were gathered along with geographic distributions.

View Article and Find Full Text PDF

Objective: To compare billing practices, reimbursement rates, and patient populations of otolaryngology (ORL) physicians practicing in rural and urban settings.

Study Design: Retrospective cross-sectional study.

Setting: Medicare Provider Utilization and Payment Data: Physician and Other Supplier Data.

View Article and Find Full Text PDF

Enteric fevers, caused by the Salmonella enterica serovars Typhi (ST), Paratyphi A (PA) and Paratyphi B (PB), are life-threatening illnesses exhibiting very similar clinical symptoms but with distinct epidemiologies, geographical distributions and susceptibilities to antimicrobial treatment. Nevertheless, the mechanisms by which the host recognizes pathogens with high levels of homology, such as these bacterial serovars, remain poorly understood. Using a three-dimensional organotypic model of the human intestinal mucosa and PA, PB, and ST, we observed significant differences in the secretion patterns of pro-inflammatory cytokines and chemokines elicited by these serovars.

View Article and Find Full Text PDF

Purpose Of Review: This article aims to provide a comprehensive review of the established and emerging applications of various computer-based technologies and smartphone applications in the field of facial plastic surgery.

Recent Findings: Computer-based technologies and smartphone applications have widespread utility across various domains of facial plastic surgery; these include preoperative consultation, surgical planning, intraoperative navigation, custom implant creation, postoperative assessment, physician productivity, communication, and education. Smartphone applications are being utilized for assessment of patients such as those with facial paralysis.

View Article and Find Full Text PDF