Smart medical report: efficient detection of common and rare diseases on common blood tests.

Introduction: The integration of AI into healthcare is widely anticipated to revolutionize medical diagnostics, enabling earlier, more accurate disease detection and personalized care.

Methods: In this study, we developed and validated an AI-assisted diagnostic support tool using only routinely ordered and broadly available blood tests to predict the presence of major chronic and acute diseases as well as rare disorders.

Results: Our model was tested on both retrospective and prospective datasets comprising over one million patients.

Assessment of Hypertensive Patients' Complex Metabolic Status Using Data Mining Methods.

Cardiovascular diseases are among the leading causes of mortality worldwide. Hypertension is a preventable risk factor leading to major cardiovascular events. We have not found a comprehensive study investigating Central and Eastern European hypertensive patients' complex metabolic status.

Determining the prevalence of childhood hypertension and its concomitant metabolic abnormalities using data mining methods in the Northeastern region of Hungary.

Objective: Identifying hypertension in children and providing treatment for it have a marked impact on the patients' long-term cardiovascular outcomes. The global prevalence of childhood hypertension is increasing, yet its investigation has been rather sporadic in Eastern Europe. Therefore, our goal was to determine the prevalence of childhood hypertension and its concomitant metabolic abnormalities using data mining methods.

Identifying Patients with Familial Chylomicronemia Syndrome Using FCS Score-Based Data Mining Methods.

Background: There are no exact data about the prevalence of familial chylomicronemia syndrome (FCS) in Central Europe. We aimed to identify FCS patients using either the FCS score proposed by Moulin et al. or with data mining, and assessed the diagnostic applicability of the FCS score.

Assessment of Associations Between Serum Lipoprotein (a) Levels and Atherosclerotic Vascular Diseases in Hungarian Patients With Familial Hypercholesterolemia Using Data Mining and Machine Learning.

Premature mortality due to atherosclerotic vascular disease is very high in Hungary in comparison with international prevalence rates, though the estimated prevalence of familial hypercholesterolemia (FH) is in line with the data of other European countries. Previous studies have shown that high lipoprotein(a)- Lp(a) levels are associated with an increased risk of atherosclerotic vascular diseases in patients with FH. We aimed to assess the associations of serum Lp(a) levels and such vascular diseases in FH using data mining methods and machine learning techniques in the Northern Great Plain region of Hungary.

Session Recommendation via Recurrent Neural Networks over Fisher Embedding Vectors.

Recommendation services bear great importance in e-commerce, shopping, tourism, and social media, as they aid the user in navigating through the items that are most relevant to their needs. In order to build recommender systems, organizations log the item consumption in their user sessions by using different sensors. For instance, Web sites use Web data loggers, museums and shopping centers rely on user in-door positioning systems to register user movement, and Location-Based Social Networks use Global Positioning System for out-door user tracking.

Identifying patients with familial hypercholesterolemia using data mining methods in the Northern Great Plain region of Hungary.

Background And Aims: Familial hypercholesterolemia (FH) is one of the most frequent diseases with monogenic inheritance. Previous data indicated that the heterozygous form occurred in 1:250 people. Based on these reports, around 36,000-40,000 people are estimated to have FH in Hungary, however, there are no exact data about the frequency of the disease in our country.

Prediction and characterization of human ageing-related proteins by using machine learning.

Ageing has a huge impact on human health and economy, but its molecular basis - regulation and mechanism - is still poorly understood. By today, more than three hundred genes (almost all of them function as protein-coding genes) have been related to human ageing. Although individual ageing-related genes or some small subsets of these genes have been intensively studied, their analysis as a whole has been highly limited.

Airway and tissue constrictions are greater in closed than in open-chest conditions.

We measured lung impedance (ZL) before and after four doses of methacholine (Mch) infusion in five intact chest (with esophageal balloon) and six open-chest dogs from 0.2 to 8 Hz with an optimal ventilator waveform. From ZL, we estimated airway resistance (R(aw)) and inertance (Iaw) and tissue viscance (GL) and elastance (HL).

Differential responses of global airway, terminal airway, and tissue impedances to histamine.

The forced oscillation and alveolar capsule techniques were applied to determine the input impedance of the lungs and the airway transfer impedances between 0.2 and 20 Hz in six open-chest dogs in the control state, during intravenous infusion of histamine at seven rates between 0.25 and 16 micrograms.

Airway and tissue mechanics during physiological breathing and bronchoconstriction in dogs.

In five open-chest dogs and with four to five alveolar capsules we used an optimal ventilator waveform (OVW) to follow frequency and tidal volume (VT) dependence of lung, airway, and tissue resistance (R) and elastance (E) before and during constant infusion of histamine (16 micrograms.kg-1.min-1).

The measurement of cardiac output in dogs by impedance cardiography with different electrode arrangements.

This study was performed to compare cardiac output (CO) values determined by means of impedance cardiography (ICG) with the conventional four-band electrode array and with different spot electrode arrays in anaesthetised dogs. CO values determined at end-expiratory apnoea with hand-calculation (ICG1) and during several respiratory cycles with a computer program (ICG2) were compared with values obtained via simultaneous thermodilution (TD) measurements. Changes in CO during isoproterenol infusion, bleeding and reinfusion were also studied by means of ICG1, using one of the spot electrode arrays and TD.

Partitioning of pulmonary impedance: modeling vs. alveolar capsule approach.

Pulmonary input impedance (ZL), transfer tissue impedances (Ztti), and transfer airway impedances (Ztaw) were measured in open-chest dogs and isolated canine lungs by means of small-amplitude pseudorandom oscillations between 0.2 and 21.1 Hz.

Mechanical impedances of lungs and chest wall in the cat.

In nine anesthetized and paralyzed cats, the mechanical impedances of the total respiratory system (Zrs) and the lungs (ZL) were measured with small-volume pseudorandom forced oscillations between 0.2 and 20 Hz. ZL was measured after thoracotomy, and chest wall impedance (Zw) was calculated as Zw = Zrs-ZL.

A comparison of interrupter and forced oscillation measurements of respiratory resistance in the dog.

We compared the values of resistance produced by the forced oscillation technique (FOT) and the flow interruption technique (IT) when applied to six anesthetized paralyzed tracheostomized dogs. The FOT returned values of respiratory system resistance as a function of frequency [Re(f)] between 0.25 and 20 Hz.

Input impedance and peripheral inhomogeneity of dog lungs.

Tracheal pressure, central airflow, and alveolar capsule pressures in cardiac lobes were measured in open-chest dogs during 0.1- to 20-Hz pseudorandom forced oscillations applied at the airway opening. In the interval 0.

Nonlinearity and harmonic distortion of dog lungs measured by low-frequency forced oscillations.

The nonlinearity of lung tissues and airways was studied in six anesthetized and paralyzed open-chest dogs by means of 0.1-Hz sinusoidal volume forcing at mean transpulmonary pressures (Ptp) of 5 and 10 cmH2O. Lung resistance (RL) and elastance (EL) were determined in a 32-fold range (15-460 ml) of tidal volume (VT), both by means of spectrum analysis at the fundamental frequency and with conventional time-domain techniques.

Mechanical impedance of the canine diaphragm. Part 2. Theoretical model and parameter estimation.

In the paper the equation of motion of the small amplitude transverse forced vibration of a radially prestressed and circularly clamped thin membrane has been developed. The material of the membrane is considered to be homogeneous, isotropic, incompressible and viscoelastic. From the analytical solution of this equation the incremental mechanical impedance of the membrane was derived as a function of frequency, geometrical parameters and incremental viscoelastic coefficients of the material.

Mechanical impedance of the canine diaphragm. Part 1. Experimental system and measurements.

A technique which does not require the measurement of strain has been developed for the investigation of the incremental dynamic properties of soft tissue sheets. Radially prestressed and circularly clamped canine diaphragm samples were exposed to small-amplitude pseudorandom pressure variations. From the measurement of these pressure variations and the volume flow caused by the vibration of the membrane the incremental mechanical impedance spectrum was computed in the 0.

Modeling of low-frequency pulmonary impedance in dogs.

The mechanical impedance of the lungs (ZL) was measured in open-chest dogs with small-amplitude pseudorandom volume oscillations between 0.125 and 5 Hz, at mean transpulmonary pressures (Ptp) of 0.2, 0.

Generation of optimum pseudorandom signals for respiratory impedance measurements.

Spontaneous breathing may impair the reliability of forced oscillatory impedance estimates at low frequencies, especially when the oscillatory power is distributed among many frequency values. Since the amplitude of the external forcing is limited to avoid non-linearities, it is suggested that the total energy of a composite electrical signal driving the loudspeaker be maximized at a given amplitude by finding the optimum phase relationships of the signal components, and that the low-frequency components increase in energy at the expense of the less disturbed high-frequency region. In healthy children and adults and in obstructed patients, the coherences and the coefficients of variation of the respiratory system impedance (Zrs) at 2 and 3 Hz were studied in the case of three test signals of 2-15 Hz bandwidth.

Low-frequency respiratory mechanical impedance in the rat.

A modified forced oscillatory technique was used to determine the respiratory mechanical impedances in anesthetized, paralyzed rats between 0.25 and 10 Hz. From the total respiratory (Zrs) and pulmonary impedance (ZL), measured with pseudorandom oscillations applied at the airway opening before and after thoracotomy, respectively, the chest wall impedance (ZW) was calculated as ZW = Zrs - ZL.

Respiratory mechanical impedance in the rat.

The forced oscillatory impedance of the total respiratory system (Zrs) was measured in seven anaesthetized, paralysed rats weighing 351 +/- 55 g. Tracheotomy was performed, and the animals were placed in the supine position in a body box. Pseudo-random pressure variations between 0.

Forced oscillatory impedance of the respiratory system at low frequencies.

Respiratory mechanical impedances were determined during voluntary apnea in five healthy subjects, by means of 0.25- to 5-Hz pseudo/random oscillations applied at the mouth. The total respiratory impedance was partitioned into pulmonary (ZL) and chest wall components with the esophageal balloon technique; corrections were made for the upper airway shunt impedance and the compressibility of alveolar gas.

Total respiratory impedance in healthy children.

Impedance of the total respiratory system was measured in 121 healthy children aged 4-16 years during spontaneous breathing by pseudo-random forced oscillations between 3 and 10 Hz. Total respiratory resistance (Rrs), inertance (Irs) and compliance (Crs) were determined by least-mean-squares fitting. Estimates for inertance were reliable only for the larger children, where the values of Irs (0.