Publications by authors named "Darja Krusova"
Article Synopsis
- A case study presented an elderly woman with systemic lambda-type AL amyloidosis, initially indicated by sudden high levels of beta-carotene and distinct skin changes.
- Diagnosis involved skin biopsies revealing lambda light chain proteins along with co-deposited proteins, leading to initial confusion.
- Ultimately, the patient died from renal failure related to amyloid nephropathy, with post-mortem examinations uncovering extensive amyloid deposits in various organs and unclear reasons for the high beta-carotene levels.
Background/aims: Complex interplay of genetic and (patho)physiological factors influence availability of nitric oxide during the development and progression of diabetic complications. We assessed predictive value of commonly studied methylated asymmetric and symmetric dimethylarginines (ADMA and SDMA) and selected single nucleotide polymorphisms (SNPs) in dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2 genes for the progression of diabetic nephropathy (DN).
Methods: A total of 341 type 1 and type 2 diabetes patients with variable degree of kidney disease were included at baseline.
Background: Pentose phosphate pathway (PPP) represents a potentially 'protective' mechanism in hyperglycaemia due to shunting of glycolytic intermediates into PPP reactions. We hypothesized that thiamine status (plasma and erythrocyte levels of thiamine and its esters) together with genetic variability in key PPP enzymes-transketolase (TKT), transaldolase and TKT-like-might contribute to the progression of diabetic nephropathy (DN) and mortality of diabetics.
Methods: A total of 240 diabetic subjects with variable degree of kidney disease were included at baseline and were followed up for a median of 26 (IQR 21-50) months.
Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of advanced glycation end products (AGEs) exerting their adverse effects via receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects.
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