Publications by authors named "Dariush Ghasemi-Semeskandeh"
Article Synopsis
- Complement is a key part of the innate immune system, and its genetic variations are linked to serious diseases.
- A study with nearly 5,000 participants identified seven genetic regions associated with different complement pathways, helping to explain up to 74% of their genetic heritability.
- Further analyses revealed specific genes that influence these pathways and their potential impact on health issues, like mouth ulcers, enhancing our understanding of how complement functions in human health.
Lower kidney function is known to enhance cardiovascular disease (CVD) risk. It is unclear which estimated glomerular filtration rate (eGFR) equation best predict an increased CVD risk and if prediction can be improved by integration of multiple kidney function markers. We performed structural equation modeling (SEM) of kidney markers and compared the performance of the resulting pooled indexes with established eGFR equations to predict CVD risk in a 10-year longitudinal population-based design.
View Article and Find Full Text PDFBackground: Previous studies have proposed different formulas of estimating glomerular filtration rate (eGFR) among clinical patients. The comprehensive comparison of eGFR formulas is not well established in a Japanese population. We compared eGFR values and chronic kidney disease (CKD) classification of nine different eGFR in a Japanese general population sample.
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