Publications by authors named "Darius W Lambiri"
Article Synopsis
- The degeneration of the maculopapillary bundle (MPB) is a key feature in various optic neuropathies, linked by mitochondrial dysfunction, despite their differing causes and symptoms.
- Recent studies using optical coherence tomography have shown changes in the retinal nerve fiber layer, indicating that the MPB can degenerate early in conditions like glaucoma.
- New insights suggest that reactive oxygen species play a role in MPB atrophy, and that anatomical factors may dictate the patterns of degeneration in glaucoma, challenging prior assumptions about its involvement in these optic neuropathies.
Leber hereditary optic neuropathy (LHON) is a rare syndrome that results in vision loss. A necessary but not sufficient condition for its onset is the existence of known mitochondrial DNA mutations that affect complex I biomolecular structure. Cybrids with LHON mutations generate higher rates of reactive oxygen species (ROS).
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