Publications by authors named "Dario Ponti"
The theory that cancer may be originated and sustained by a small proportion of stem-like, self-renewing cells (termed 'cancer stem cells') has gained support in recent years. Breast cancer stem cells have been identified as CD44+CD24- breast tumour cells and have recently been isolated and propagated in vitro. It has been demonstrated that these cells exclusively retain the ability to form new tumours in mouse models and that they display stem/progenitor cell properties.
View Article and Find Full Text PDFBreast cancer-initiating cells have been recently identified in breast carcinoma as CD44+/CD24(-/low) cells, which exclusively retain tumorigenic activity and display stem cell-like properties. However, at present, direct evidence that breast cancer-initiating cells can be propagated in vitro is still lacking. We report here the isolation and in vitro propagation of breast cancer-initiating cells from three breast cancer lesions and from an established breast carcinoma cell line.
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- Neural stem cells can be sourced from both adult and embryonic nervous systems, but distinguishing them is challenging due to undefined markers.
- Researchers have identified various endothelial and hematopoietic receptors on embryonic human neural stem cells, which are partly retained as these cells differentiate.
- This finding implies that neural stem cells possess a broader capability than assumed, enabling them to respond to diverse environmental signals and potentially influencing stem cell fate conversion.