Publications by authors named "Dario Angelo Alberto Vignali"

Background: The influence of donor-side regulation toward recipient antigens on graft outcome is poorly understood.

Methods: Because this influence might be due in part to the accumulation of tissue-resident memory T cells in the donor organ, we used a standard murine tolerization model (donor-specific transfusion plus CD40L blockade) to determine the kinetics of development and peripheralization of allospecific regulatory T cell in lymphoid tissues and liver, a secondary lymphoid organ used in transplantation.

Results: We found that donor-specific transfusion and CD40L blockade leads to a progressive and sustained T regulatory allospecific response.

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