Publications by authors named "Dario Alvarez"
Article Synopsis
- Myelinated axons transmit signals in the brain through action potentials, but accurately mapping their crossing paths is challenging due to influence from unrelated brain structures.
- Small-angle X-ray scattering (SAXS) can specifically detect myelinated axons by identifying distinct peaks in their scattering patterns, allowing for better resolution of fiber crossings.
- The study demonstrates SAXS's effectiveness in various brain samples and positions it as a reliable tool for validating fiber orientations obtained from other imaging techniques like diffusion MRI and microscopy.
Background: Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness.
Methods: We conducted a randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older adult patients within 72 hours after the onset of mild Covid-19 symptoms.