Calmodulin-Calcineurin Interaction beyond the Calmodulin-Binding Region Contributes to Calcineurin Activation.

Calcineurin (CaN) is a calcium-dependent phosphatase involved in numerous signaling pathways. Its activation is in part driven by the binding of calmodulin (CaM) to a CaM recognition region (CaMBR) within CaN's regulatory domain (RD). However, secondary interactions between CaM and the CaN RD may be necessary to fully activate CaN.

Beneficial re-use of industrial CO emissions using microalgae: Demonstration assessment and biomass characterization.

A novel cyclic flow photobioreactor, designed for the capture and recycle of CO using microalgae, was deployed at a coal-fired power plant. Scenedesmus acutus was cultured continuously for a four-month period, during which a biomass productivity of 0.1-0.

Simulation of P2X-mediated calcium signalling in microglia.

Key Points: A computational model of P2X channel activation in microglia was developed that includes downfield Ca -dependent signalling pathways. This model provides quantitative insights into how diverse signalling pathways in microglia converge to control microglial function.

Abstract: Microglia function is orchestrated through highly coupled signalling pathways that depend on calcium (Ca ).