Publications by authors named "Darin Jeekin Chin"
Article Synopsis
- The HIV-1 gp41 core structure is a stable six-helix bundle formed by heptad-repeat sequences, with a hydrophobic cavity on its surface that is a key target for anti-HIV fusion inhibitors.
- Recent research has identified small molecule inhibitors that bind to this cavity and disrupt the formation of the six-helix bundle, which is essential for HIV infection.
- Analysis of the positively charged residue Lys574 revealed that mutations at this site completely eliminate viral infectivity and greatly reduce the stability of the six-helix bundles, highlighting its importance as a target in developing anti-HIV therapies.
