Simulation of P2X-mediated calcium signalling in microglia.

Key Points: A computational model of P2X channel activation in microglia was developed that includes downfield Ca -dependent signalling pathways. This model provides quantitative insights into how diverse signalling pathways in microglia converge to control microglial function.

Abstract: Microglia function is orchestrated through highly coupled signalling pathways that depend on calcium (Ca ).