Publications by authors named "Darien Z H Chan"
Since December 2019, the novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected ~435 million people and caused ~6 million related deaths as of March 2022. To combat COVID-19, there have been many attempts to repurpose FDA-approved drugs or revive old drugs. However, many of the current treatment options have been known to cause adverse drug reactions.
View Article and Find Full Text PDFThe advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the molecular mechanisms of human disease, drug discovery, and regenerative medicine. As such, the use of iPSCs in drug development and validation has shown a sharp increase in the past 15 years. Furthermore, many labs have been successful in reproducing many disease phenotypes, often difficult or impossible to capture, in commonly used cell lines or animal models.
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- * By differentiating these hiPSCs into cardiomyocytes and neurons, we conducted high-throughput toxicity screenings and validated our findings through dose-dependent toxicity assessments and functional modulation.
- * Our research demonstrated that this population-based hiPSC platform is a practical approach for studying drug toxicity, helping illuminate differences across populations and enhancing drug discovery processes.