Identification of genetic markers of resistance to macrolide class antibiotics in isolates from a Saskatchewan feedlot.

is a major contributor to bovine respiratory disease (BRD), which causes substantial economic losses to the beef industry, and there is an urgent need for rapid and accurate diagnostic tests to provide evidence for treatment decisions and support antimicrobial stewardship. Diagnostic sequencing can provide information about antimicrobial resistance genes in more rapidly than conventional diagnostics. Realizing the full potential of diagnostic sequencing requires a comprehensive understanding of the genetic markers of antimicrobial resistance.

Complete genome sequence of isolated from a healthy feedlot calf in Saskatchewan, Canada.

A lack of whole genome sequences for spp. other than complicates their identification. Here, we present the genome sequence of 39324.

Changes in the phenotypic susceptibility of isolates to macrolide antimicrobials during the early feeding period following metaphylactic tulathromycin use in western Canadian feedlot calves.

Cattle at high-risk for bovine respiratory disease on entry to western Canadian feedlots are often treated metaphylactically with antimicrobials from the macrolide class. High levels of resistance to macrolides have been reported in isolates from clinical samples, but it is less clear whether this trend extends to the broader feedlot population. The objective was to describe near-term [< 40 days on feed (DOF)] changes in the recovery and susceptibility of isolates from healthy feedlot calves after metaphylactic exposure to tulathromycin.