Publications by authors named "Dariel Arrechaga-Estevez"
Int J Mol Sci
January 2021
Article Synopsis
- Ion channels are essential protein complexes in cell membranes; their dysfunction leads to channelopathies, significant disorders that are challenging to study and treat.
- The review focuses on voltage-gated potassium channels, especially the K4-family, and their roles in generating electrical currents in heart and brain cells, linking them to serious conditions like Brugada syndrome and schizophrenia.
- It explores the interactions between K4 channels and accessory subunits (β), aiming to enhance understanding of their mechanisms and potential treatments through research on small molecule KChIP ligands affecting channel activity.
