Publications by authors named "Daria V Tsvirkun"
Calcium plays a role of universal cellular regulator in the living cell and one of the crucial regulators of proper fetal development during gestation. Mitochondria are important for intracellular calcium handling and signaling. Mitochondrial calcium uniporter (mtCU) is a multiprotein complex of the mitochondrial inner membrane responsible for the transport of calcium to the mitochondrial matrix.
View Article and Find Full Text PDFMost studies have considered the negative influence of obesity on fertility in both genders. In the present study, we assessed mitochondrial activity expressed as the mitochondrial potential index (MPI) in cumulus cells from obese women and women with a normal body mass index (BMI) during assisted reproductive therapy. The results revealed a significant reduction of MPI with increased body mass.
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- Preeclampsia (PE) is a pregnancy-related condition that leads to high blood pressure and can cause serious health issues for both mothers and babies, yet its exact cause is still unknown.
- This study involved 38 pregnant women categorized into three groups: those with normal pregnancies, early-onset PE, and late-onset PE, focusing on analyzing the cells and mitochondria in the placenta.
- Findings showed that early-onset PE placentas had increased levels of certain mitochondrial-related proteins and DNA copy numbers, indicating that changes in mitochondrial activity may play a significant role in how PE develops.