Publications by authors named "Daria Starkova"
Article Synopsis
- Clarithromycin (CLR) is a crucial antibiotic for treating Helicobacter pylori infections, but there is a lack of data on resistance patterns in Russia.
- Researchers used whole genome sequencing (WGS) to analyze 44 clinical H. pylori isolates from 2014-2022, finding that 23 were CLR-resistant while 21 were susceptible.
- The study identified specific genetic mutations in the 23S rRNA gene that reliably predict resistance, and it also compared mutations in virulence-related genes between resistant and susceptible strains, highlighting a significant deletion in the HP0820 gene as a key area for future research.
Article Synopsis
- The study investigates the genetic variations in Bacille Calmette-Guérin (BCG) vaccine strains, specifically focusing on seed lots used in Russia and their descendants linked to BCG-related diseases in children.
- Through whole-genome sequencing, researchers compared seed lots 361, 367, and 368 with nine progeny isolates and identified specific genetic mutations that could influence vaccine efficacy and virulence.
- The findings suggest that while genetic variations exist, they did not compromise the stability or effectiveness of the BCG vaccine, indicating that changes accumulate during the vaccine's time in the human body.
Article Synopsis
- Japan has a high incidence rate of nontuberculous mycobacterial lung disease, primarily caused by Mycobacterium avium subsp. hominissuis (MAH), with environmental sources like bathrooms suspected to be key infection points.
- A study analyzed samples from 180 residences and found a 16.1% detection rate of MAH, varying by region, with higher rates in Kanto and Kinki compared to much lower rates in other regions.
- Genetic analysis indicated that MAH from bathrooms showed significant genetic similarities to isolates from lung disease patients in Japan, reinforcing the idea that bathrooms are important potential sources of MAH infection.
Microbial production of lipid-protein vesicles using enveloped bacteriophage phi6.
Microb Cell Fact
February 2019
Background: Cystoviruses have a phospholipid envelope around their nucleocapsid. Such a feature is unique among bacterial viruses (i.e.
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- Mycobacterium avium subsp. hominissuis (MAH) is a common non-tuberculous mycobacterium linked to chronic lung disease, but its genetic evolution remains poorly understood.
- A study analyzed the genetic structure and recombination of 36 global MAH isolates, revealing five major lineages with significant genetic exchange, especially among Japanese strains.
- Unique genetic alleles related to trehalose biosynthesis and mammalian cell entry were identified in East Asian lineages, indicating a role of recombination in local adaptation and genetic diversity.
Background: Russian Republic of Karelia is located at the Russian-Finnish border. It contains most of the historical Karelia land inhabited with autochthonous Karels and more recently migrated Russians. Although tuberculosis (TB) incidence in Karelia is decreasing, it remains high (45.
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