Publications by authors named "Daria Sehr"
Myosin motors are critical for diverse motility functions, ranging from cytokinesis and endocytosis to muscle contraction. The UNC-45 chaperone controls myosin function mediating the folding, assembly, and degradation of the muscle protein. Here, we analyze the molecular mechanism of UNC-45 as a hub in myosin quality control.
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- The growing issue of antimicrobial resistance highlights the urgent need for new treatments against Mycobacterium tuberculosis (Mtb), leading researchers to explore callyaerins, a class of unique hydrophobic cyclopeptides, as potential anti-tubercular agents.
- Callyaerins are effective against various strains of Mtb, including those resistant to existing antibiotics, showing minimal harm to human cells and strong intracellular activity.
- Studies reveal that callyaerins target a specific membrane protein in Mtb, Rv2113, causing significant disturbances in vital cellular processes like lipid synthesis and DNA repair, indicating that even non-essential proteins could be promising targets for new antimycobacterial drugs.