Publications by authors named "Daria Pawlik"
Article Synopsis
- The study evaluated the correlation between the in vivo PET tracer [F]flortaucipir and post-mortem tau pathology in Alzheimer's disease patients, analyzing brain regions from 63 participants who underwent PET scans prior to death.
- Results showed modest-to-strong correlations between [F]flortaucipir uptake and tau pathology density in neocortical areas, especially in regions related to Alzheimer's disease.
- However, no significant associations were found between [F]flortaucipir and markers of other pathologies like amyloid-β plaques or TDP-43 in individuals with possible primary age-related tauopathy, indicating the tracer's specificity for tau detection.
Importance: It is important to determine the added clinical value for tau positron emission tomography (PET) in the diagnostic workup of patients with cognitive symptoms before widespread implementation in clinical practice.
Objective: To prospectively study the added clinical value of PET detecting tau pathology in Alzheimer disease (AD).
Design, Setting, And Participants: This prospective cohort study (Swedish BioFINDER-2 study) took place from May 2017 through September 2021.
Introduction: The diagnosis of progressive supranuclear palsy (PSP) is often challenging since PSP may clinically resemble other neurodegenerative disorders. Recently, the tau PET tracer [F]RO948, a potential new biomarker for PSP, was developed. The aim of this study was to determine the ability of three different biomarkers, including [F]RO948 PET, to distinguish PSP patients from healthy controls and from patients with α-synucleinopathies.
View Article and Find Full Text PDFPurpose: The hippocampus is affected by tau pathology early in Alzheimer's disease (AD) development. Accurate quantification of hippocampal tau signal using the tau-PET tracer F-flortaucipir is complicated, however, by off-target binding in the adjacent choroid plexus. We here present a new method for compensating for this off-target choroid plexus signal.
View Article and Find Full Text PDFImportance: In Alzheimer disease (AD), tau filaments form neuronal inclusions in neurites (neuropil threads) and in somata (neurofibrillary tangles), and neurite tau pathology constitutes the most common pathology. Positron emission tomography (PET) ligands have been developed to detect in vivo tau pathology in AD. However, the association of AD tau pathology post mortem with in vivo tau PET retention has not been established.
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