Publications by authors named "Daria Larocca"
Changes in the function and microbiome of the upper and lower gastrointestinal tract have been documented in Parkinson's disease (PD), although most studies have examined merely fecal microbiome profiles and patients with advanced disease states. In the present study we sought to identify sensitive and specific biomarkers of changes in the oral microbiome of early stage PD through shotgun metatranscriptomic profiling. We recruited 48 PD subjects and 36 age- and gender-matched healthy controls.
View Article and Find Full Text PDFTraumatic brain injury (TBI) is a major cause of death and disability worldwide, with mild TBI (mTBI) accounting for 85% of cases. mTBI is also implicated in serious long-term sequelae including second impact syndrome and chronic traumatic encephalopathy. mTBI often goes undiagnosed due to delayed symptom onset and limited sensitivity of conventional assessment measures compared with severe TBI.
View Article and Find Full Text PDFArticle Synopsis
- The study highlights that SHP-1 deficiency in motheaten mice leads to reduced myelination and myelin basic protein (MBP) expression in the central nervous system, correlating with lower MBP mRNA levels.
- SHP-1 appears to play a critical role in regulating oligodendrocyte gene expression and function, as evidenced by higher levels of reactive oxygen species (ROS) and oxidative stress markers in SHP-1 deficient cells.
- The findings suggest that antioxidant treatment can reverse the negative effects in SHP-1-deficient oligodendrocytes, and there's also an implication of SHP-1 expression in human oligodendrocytes, particularly in multiple sclerosis patients.
Background: The aggregation of specific proteins is a common feature of the familial dementias, but whether the formation of neuronal inclusion bodies is a causative or incidental factor in the disease is not known. To clarify this issue, we investigated five families with typical neuroserpin inclusion bodies but with various neurological manifestations.
Methods: Five families with neurodegenerative disease and typical neuronal inclusions had biopsy or autopsy material available for further examination.