Publications by authors named "Daria Goncharova"

Article Synopsis
  • Membrane-associated 70 kDa heat shock protein (mHsp70) plays a crucial role in the migration and invasion of malignant brain tumor cells, as observed in patient samples.
  • Advanced techniques like inverted confocal microscopy and mass spectrometry showed that mHsp70 is prominently expressed on the surface of cancer cells, particularly in areas surrounding the tumors.
  • Inhibiting HSP70 with small molecules significantly reduced cancer cell invasiveness and delayed tumor progression in animal models, suggesting that targeting mHsp70 could be a promising strategy for developing new cancer therapies.
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Hydrosphere pollution by organic pollutants of different nature (persistent dyes, phenols, herbicides, antibiotics, etc.) is one of the urgent ecological problems facing humankind these days. The task of water purification from such pollutants can be effectively solved with the help of modern photocatalytic technologies.

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Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic (i.e., theranostic) potencies in translational oncology, and some agents have been further translated into clinical trials.

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In the present study, wound healing ferroelectric membranes doped with zinc oxide nanoparticles were fabricated from vinylidene fluoride-tetrafluoroethylene copolymer and polyvinylpyrrolidone using the electrospinning technique. Five different ratios of vinylidene fluoride-tetrafluoroethylene to polyvinylpyrrolidone were used to control the properties of the membranes at a constant zinc oxide nanoparticle content. It was found that an increase of polyvinylpyrrolidone content leads to a decrease of the spinning solution conductivity and viscosity, causing a decrease of the average fiber diameter and reducing their strength and elongation.

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These days, composite materials based on polymers and inorganic nanoparticles (NPs) are widely used in optoelectronics and biomedicine. In this work, composite membranes of polylactic acid and ZnO NPs containing 5-40 wt.% of the latter NPs were produced by means of electrospinning.

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Here, we report on ZnO nanoparticles (NPs) generated by nanosecond pulsed laser (Nd:YAG, 1064 nm) through ablation of metallic Zn target in water and air and their comparative analysis as potential nanomaterials for biomedical applications. The prepared nanomaterials were carefully characterized in terms of their structure, composition, morphology and defects. It was found that in addition to the main wurtzite ZnO phase, which is conventionally prepared and reported by others, the sample laser generated in air also contained some amount of monoclinic zinc hydroxynitrate.

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