Publications by authors named "Daria Chupova"
Objective: Non-invasive surgical approaches, including boiling histotripsy (BH), are currently being developed for the treatment of brain disorders aiming to avoid craniotomy and exposure of intervening tissues, and, thus, minimize associated complications. This work aimed to demonstrate the feasibility of BH for mechanical fractionation of human brain tissues ex vivo under B-mode guidance, with preliminary measurements of tissue stiffness via shear wave elastography.
Methods: Young's moduli of 25 human autopsy brain samples obtained from de-identified patients of 51-91 y old (median 77 y old) were measured via shear wave elastography prior to BH sonication.
Objective: As an alternative to surgical excision and magnetic resonance-guided thermal high-intensity focused ultrasound ablation of uterine leiomyoma, this work was aimed at pilot feasibility demonstration of use of ultrasound-guided boiling histotripsy for non-invasive non-thermal fractionation of human uterine leiomyoma ex vivo.
Methods: A custom-made sector ultrasound transducer of 1.5-MHz operating frequency and nominal f-number F# = 0.