Publications by authors named "Daria Butuzova"
Int J Mol Sci
December 2023
Article Synopsis
- Multipotent mesenchymal stromal cells (MSCs) play a crucial role in tissue repair by secreting proteins that can inhibit fibrosis development, particularly by affecting fibroblast differentiation into myofibroblasts.
- Research showed that dividing MSC secretome into subfractions—extracellular vesicles (EV) and soluble factors (SF)—enhances their antifibrotic effects in lab settings by preventing this differentiation.
- A proteomic analysis indicated that conditioned medium (CM) from MSCs contains activators of the NF-κB pathway, which helps regulate gene expression related to fibroblast function, while EV and SF are rich in factors associated with important signaling pathways, influencing therapeutic strategies involving MSCs.
